All Phenotypes Vcl<tm1Ross> MGI Mouse

premature death ( J:129075 )

• mice exhibit sudden deaths with no symptoms of cardiomyopathy at young ages (6 weeks) and signs of heart failure at older ages (14 months)

• at 14 weeks, 49% of males die suddenly without any defects in cardiac contractile function

increased heart weight ( J:129075 )

• heart weight to body weight and heart weight to tibia length are increased

cardiac hypertrophy ( J:129075 )

dilated heart left ventricle ( J:129075 )

• mice exhibit progressive dilation of the left ventricle during systole and diastole that parallels the decline in ventricular function

cardiac fibrosis ( J:129075 )

dilated cardiomyopathy ( J:129075 )

• mutants that do not die suddenly, develop dilated cardiomyopathy as they age

• as mice age they display reduced percent fractional shortening and velocity of circumferential fiber shortening

• at high doses of dobutamine left ventricle relaxation is abnormal indicating mild diastolic dysfunction

ventricular tachycardia ( J:129075 )

• young mice exhibit polymorphic ventricular tachycardia

irregular heartbeat ( J:129075 )

• older mice exhibit arrhythmias that are not found in wild-type mice

• 86% of mice exhibit ectopy

• during apical pacing, hearts display a disturbed front wave propagation and greater negative front wave curvature compared to in wild-type mice

heart block ( J:129075 )

• young mice exhibit heart block

congestive heart failure ( J:129075 )

• mice that die after 14 weeks exhibit signs, symptoms and postmortem evidence of heart failure