Vcl^tm1Ross
Targeted Allele Detail

Summary

• Symbol: Vcl^tm1Ross
• Name: vinculin; targeted mutation 1, Robert S Ross
• MGI ID: MGI:3769142
• Synonyms: Vcl^fl, Vcl^flx
• Gene: Vcl Location: Chr14:20979466-21083744 bp, + strand Genetic Position: Chr14, 11.53 cM
• Alliance: Vcl^tm1Ross page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129075
• Parent Cell Line: LW1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 3. An additional loxP site was inserted upstream of exon 3. Flp-mediated recombination was used to remove the neo cassette leaving a floxed exon 3. (J:129075)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vcl Mutation: 48 strains or lines available

References

• Original: J:129075 Zemljic-Harpf AE, et al., Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol. 2007 Nov;27(21):7522-37
• All: 10 reference(s)