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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Myh7)102Rbns
transgene insertion 102, Jeffrey Robbins
MGI:3769140
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-Myh7)102Rbns/Tg(Myh6-Myh7)102Rbns involves: FVB/N MGI:4839902
tg2
Tg(Myh6-Myh7)102Rbns/? involves: FVB/N MGI:3769141


Genotype
MGI:4839902
tg1
Allelic
Composition
Tg(Myh6-Myh7)102Rbns/Tg(Myh6-Myh7)102Rbns
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal left atrial size
• atrial weight is increased prior to and following isoproterenol treatment compared with similarly treated wild-type mice
• 8 weeks after coronary ligation, mice exhibit increased left ventricle end-diastolic diameter compared with similarly treated wild-type mice
• 6 and 8 weeks after coronary ligation, mice exhibit increased left ventricle end-systolic diameter compared with similarly treated wild-type mice
• after swim training, left ventricle end-systolic free wall thickness is not increased compared to in similarly treated wild-type mice
• following coronary ligation
• after isoproterenol treatment compared with similarly treated wild-type mice
• following coronary ligation at 8 weeks
• dobutamine-treated mice exhibit decreased left ventricular systolic peak pressure compared with similarly treated wild-type mice
• following coronary ligation mice exhibit increased left ventricle and lung weight, decreased fractional shortening, and increased left ventricle end-diastolic and -systolic diameter compared with similarly treated wild-type mice
• 24 hours and 2 weeks after isoproterenol treatment compared with similarly treated wild-type mice

homeostasis/metabolism
• following coronary ligation mice exhibit increased left ventricle and lung weight, decreased fractional shortening, and increased left ventricle end-diastolic and -systolic diameter compared with similarly treated wild-type mice
• dobutamine-treated mice exhibit decreased left ventricular systolic peak pressure compared with similarly treated wild-type mice
• after isoproterenol treatment, mice exhibit increased left and right ventricle weight, atrial weight, and decreased systolic blood pressure compared with similarly treated wild-type mice

muscle
• following coronary ligation at 8 weeks

respiratory system
• following coronary ligation

growth/size/body
• following coronary ligation




Genotype
MGI:3769141
tg2
Allelic
Composition
Tg(Myh6-Myh7)102Rbns/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• energy efficiency is increased
• however, heart function is normal
• cross-bridge cycling rates are altered
• however, heart morphology and physiology are normal





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory