Tg(Myh6-Myh7)102Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Myh7)102Rbns
• Name: transgene insertion 102, Jeffrey Robbins
• MGI ID: MGI:3769140
• Synonyms: beta-TG
• Transgene: Tg(Myh6-Myh7)102Rbns Location: unknown
• Alliance: Tg(Myh6-Myh7)102Rbns page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Myh7)102Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myh7 (MGI:2155600)

• Mutation details: The expression of Myh7 is driven by the Myh6 promoter to accomplish replacement of myosin heavy chains in cardiac tissue. (J:128692)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

5 lines were created with between 1.7 and 3.3-fold overexpression. Line 102 was chosen as the representative line because it exhibits 83% ventricular replacement of Myh6 with Myh7.

References

• Original: J:128692 Krenz M, et al., Analysis of myosin heavy chain functionality in the heart. J Biol Chem. 2003 May 9;278(19):17466-74
• All: 8 reference(s)