Analysis Tools
mortality/aging
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• no homozygotes are seen at E18.5
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Allele Symbol Allele Name Allele ID |
Del(11Mpo-Chad)18Brd deletion, Chr 11, Allan Bradley 18 MGI:3766573 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no homozygotes are seen at E18.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• majority of heterozygotes are born alive, however about 15% die within several hours of birth
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• 5 of 38 mutants display a hypoplastic pulmonary trunk
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• 32% of E18.5 fetuses exhibit structural heart defects
• 5 of 38 mutants exhibit two or more abnormalities that are characteristic of the tetralogy of Fallot complex, including perimembranous ventricular septal defects, overriding of the aorta, and hypoplastic pulmonary trunks
• howerver, mutants do not develop patent ductus arteriosus and dilated left atrium and ventricle
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• seen in 5 of 38 mutants at E18.5
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• 8 of 38 fetuses exhibit transposition of the great arteries
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• 7 of 38 mutants have perimembranous ventricular septal defects
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• 8 of 38 mutants have inlet ventricular septal defects
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• 4 of 38 mutants exhibit deviation of the parietal muscle band which causes subpulmonary stenosis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dextro-looped transposition of the great arteries | DOID:0060770 |
OMIM:608808 |
J:109163 | |
| tetralogy of Fallot | DOID:6419 |
OMIM:187500 |
J:109163 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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