Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation
(1 available);
any
Gata4 mutation
(36 available)
Tg(Myh6-Map2k1*)1Jmol mutation
(1 available)
Tg(Myh7-cre)1Jmk mutation
(0 available)
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cardiovascular system
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• hypertrophy is markedly attenuated compared to mutant mice not expressing cre
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Jmol mutation
(1 available);
any
Gata4 mutation
(36 available)
Tg(Myh6-Map2k1*)1Jmol mutation
(1 available)
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cardiovascular system
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• hypertrophy is markedly attenuated compared to transgenic mice wild-type for Gata4
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation
(1 available);
any
Gata4 mutation
(36 available)
Tg(Myh6-Map2k1*)1Jmol mutation
(1 available)
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cardiovascular system
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• about a 30% increase in ventricular weight compared to mutant mice not carrying the transgene
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growth/size/body
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• about a 30% increase in ventricular weight compared to mutant mice not carrying the transgene
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Melo mutation
(0 available);
any
Mapk1 mutation
(40 available)
Tg(Myh6-Map2k1*)1Jmol mutation
(1 available)
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cardiovascular system
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• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals
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growth/size/body
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• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3tm1Gpg mutation
(1 available);
any
Mapk3 mutation
(26 available)
Tg(Myh6-Map2k1*)1Jmol mutation
(1 available)
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cardiovascular system
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• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals
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growth/size/body
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• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Map2k1*)1Jmol mutation
(1 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation
(1 available)
Tg(Myh6-tTA)55Rbns mutation
(2 available)
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cardiovascular system
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• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol and wild-type mice
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• compared with wild-type mice
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• left ventricular wall thickness is increased compared with wild-type and Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
• however, left ventricle size is rescued compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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muscle
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• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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growth/size/body
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• compared with wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Map2k1*)1Jmol mutation
(1 available)
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cardiovascular system
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• about 30% increase in the cross-sectional area of each myocardial fiber
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• there is about a 50% increase left ventricular posterior wall thickness
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• increased heart:body weight ratio of 34, 41, and 23% is observed at 3 weeks, 8 weeks, and 6 months of age
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• there is about a 50% increase in septal thickness and left ventricular posterior wall thickness
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• diastolic function is reduced due to decreased ventricular volume
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• greater than 10% increase in left ventricular systolic pressure
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• less apoptosis is observed in mice subjected to ischemia/reperfusion of the left coronary artery
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muscle
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• about 30% increase in the cross-sectional area of each myocardial fiber
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• there is about a 50% increase left ventricular posterior wall thickness
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• less apoptosis is observed in mice subjected to ischemia/reperfusion of the left coronary artery
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cellular
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• less apoptosis is observed in mice subjected to ischemia/reperfusion of the left coronary artery
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growth/size/body
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• there is about a 50% increase left ventricular posterior wall thickness
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• increased heart:body weight ratio of 34, 41, and 23% is observed at 3 weeks, 8 weeks, and 6 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Map2k1*)1Jmol mutation
(1 available)
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cardiovascular system
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• 7 days after ischemia injury, mice have no loss of cardiac output compared to 50% loss in wild-type controls
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• eight fold less cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury
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• there is two-third less infarction of the left ventricular area after ischemia/reperfusion injury
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muscle
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• eight fold less cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury
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homeostasis/metabolism
cellular
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• eight fold less cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury
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Analysis Tools
