All Phenotypes Hesx1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hesx1⁺
wild type
MGI:3766119

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hesx1^tm1Icar/Hesx1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3766120
ht2	Hesx1^tm1(cre)Jpmb/Hesx1⁺	involves: 129S/SvEv * C57BL/6	MGI:5314529
cn3	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1⁺	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:3822878
cn4	Hesx1^tm1(cre)Jpmb/Hesx1⁺ Tcf7l1^tm1Efu/Tcf7l1^tm2Efu	involves: 129S/SvEv * C57BL/6	MGI:5314534
cx5	Hesx1^tm1Icar/Hesx1⁺ Tcf7l1^tm2Efu/Tcf7l1⁺	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:5314532

Allelic Composition	Hesx1^tm1Icar/Hesx1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1^tm1Icar mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain morphology ( J:47920 )

• 1% of mice exhibit the mild phenotype associated with homozygous mice

respiratory system

abnormal nose morphology ( J:47920 )

• 1% of mice exhibit the mild phenotype associated with homozygous mice

vision/eye

abnormal eye morphology ( J:47920 )

• 1% of mice exhibit the mild phenotype associated with homozygous mice

craniofacial

abnormal craniofacial morphology ( J:47920 )

• 1% of mice exhibit the mild phenotype associated with homozygous mice

abnormal nose morphology ( J:47920 )

• 1% of mice exhibit the mild phenotype associated with homozygous mice

growth/size/body

abnormal nose morphology ( J:47920 )

• 1% of mice exhibit the mild phenotype associated with homozygous mice

Allelic Composition	Hesx1^tm1(cre)Jpmb/Hesx1⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

microphthalmia ( J:181005 )

• low incidence of unilateral microphthalmia

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (10 available); any Gt(ROSA)26Sor mutation (1095 available)
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:142649 )

Allelic Composition	Hesx1^tm1(cre)Jpmb/Hesx1⁺ Tcf7l1^tm1Efu/Tcf7l1^tm2Efu
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1^tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
Tcf7l1^tm1Efu mutation (0 available); any Tcf7l1 mutation (84 available)
Tcf7l1^tm2Efu mutation (0 available); any Tcf7l1 mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

microphthalmia ( J:181005 )

• unilateral in some mice

• bilateral in some mice

anophthalmia ( J:181005 )

• unilateral in some mice

• bilateral in some mice

nervous system

small embryonic telencephalon ( J:181005 )

• in some mice

decreased forebrain size ( J:181005 )

• severe truncation in some mice

Allelic Composition	Hesx1^tm1Icar/Hesx1⁺ Tcf7l1^tm2Efu/Tcf7l1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1^tm1Icar mutation (0 available); any Hesx1 mutation (14 available)
Tcf7l1^tm2Efu mutation (0 available); any Tcf7l1 mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

microphthalmia ( J:181005 )

• unilateral in some mice

• bilateral in some mice

anophthalmia ( J:181005 )

• unilateral in some mice

nervous system

small embryonic telencephalon ( J:181005 )

• in some mice

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