Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnf)6074Gkl mutation
(1 available)
Tnfrsf1btm1Mwm mutation
(2 available);
any
Tnfrsf1b mutation
(30 available)
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nervous system
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• cerebellum myelin vacuolation in 4 week old mice
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immune system
cellular
Allelic
Composition |
Tg(Tnf)6074Gkl/0
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Genetic
Background |
involves: C57BL/6 * CBA |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnf)6074Gkl mutation
(1 available)
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nervous system
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• at 1 week of age there is widespread microglial activation
• at 8-10 weeks plaque edge cells contain myelin degradation products
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• at 8-10 weeks of age some astroglial scarring
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• minimal blood-brain barrier damage and immune infiltration can be observed at the meninges at 1 week of age
• at 4 weeks of age pronounced inflammation at the brain meninges
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• at 8-10 weeks of age moderate axonal damage is evident within plaques
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• at 1 week of age TUNEL+ cells characteristic of apoptosis are found in the corpus callosum
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• at 8-10 weeks of age signs of BBB leakage
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• oligodendrocyte apoptosis starting at 1 week of age
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• T lymphocyte infiltration in the cerebellum at 8-10 weeks of age
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• early demyelinating events consisting of myelin swelling and the formation of vacuoles with single fiber degeneration at 4 weeks of age
• by 8-10 weeks of age confluent symmetrical plaques of primary demyelination develop within the cerebellar white matter, the capsula interna and to a minor degree, the optic tracts
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hematopoietic system
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• at 1 week of age there is widespread microglial activation
• at 8-10 weeks plaque edge cells contain myelin degradation products
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immune system
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• at 1 week of age there is widespread microglial activation
• at 8-10 weeks plaque edge cells contain myelin degradation products
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• T lymphocyte infiltration in the cerebellum at 8-10 weeks of age
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cardiovascular system
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• at 8-10 weeks of age signs of BBB leakage
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cellular
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• oligodendrocyte apoptosis starting at 1 week of age
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Analysis Tools