Phenotypes associated with this allele
taste/olfaction
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• olfactory sensory neurons are absent in the dorsal zone of the olfactory bulb epithelium
• mitral cells fail to form dendrtic terminal tufts indicating a lack of synaptic input
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• no expression of class I or class II olfactory receptor genes in the dorsal zone of the olfactory epithelium
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• there are decreased numbers of activated cells in the bed nucleus of the stria terminalis after exposure to the odorant trimethyl-thiazoline
• the glomeruli of the dorsal zone of the olfactory bulb fail to detect several different odors
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behavior/neurological
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• mice are able to discriminate between structurally related odorants including trimethyl-thiazoline and 2-methylbutyric acid
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• mice fail to show innate avoidance behavior to unpleasant scents including trimethyl-thiazoline (found in fox urine) and 2-methylbutyric acid (found in spoiled foods)
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nervous system
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• olfactory sensory neurons are absent in the dorsal zone of the olfactory bulb epithelium
• mitral cells fail to form dendrtic terminal tufts indicating a lack of synaptic input
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• no expression of class I or class II olfactory receptor genes in the dorsal zone of the olfactory epithelium
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craniofacial
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• olfactory sensory neurons are absent in the dorsal zone of the olfactory bulb epithelium
• mitral cells fail to form dendrtic terminal tufts indicating a lack of synaptic input
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• no expression of class I or class II olfactory receptor genes in the dorsal zone of the olfactory epithelium
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respiratory system
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• olfactory sensory neurons are absent in the dorsal zone of the olfactory bulb epithelium
• mitral cells fail to form dendrtic terminal tufts indicating a lack of synaptic input
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• no expression of class I or class II olfactory receptor genes in the dorsal zone of the olfactory epithelium
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growth/size/body
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• olfactory sensory neurons are absent in the dorsal zone of the olfactory bulb epithelium
• mitral cells fail to form dendrtic terminal tufts indicating a lack of synaptic input
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• no expression of class I or class II olfactory receptor genes in the dorsal zone of the olfactory epithelium
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eno2tm1(DTA)Hsak mutation
(1 available);
any
Eno2 mutation
(53 available)
Tg(Or10j5-cre,-ECFP)17Hsak mutation
(0 available)
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taste/olfaction
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• olfactory sensory neurons are absent in the ventral zone and in some of the dorsal zone of the olfactory bulb epithelium
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• no expression of class II olfactory receptor genes in the dorsal or ventral zones of the olfactory epithelium
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behavior/neurological
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• mice fail to show innate avoidance behavior to trimethyl-thiazoline scent (found in fox urine)
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nervous system
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• olfactory sensory neurons are absent in the ventral zone and in some of the dorsal zone of the olfactory bulb epithelium
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• no expression of class II olfactory receptor genes in the dorsal or ventral zones of the olfactory epithelium
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craniofacial
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• olfactory sensory neurons are absent in the ventral zone and in some of the dorsal zone of the olfactory bulb epithelium
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• no expression of class II olfactory receptor genes in the dorsal or ventral zones of the olfactory epithelium
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respiratory system
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• olfactory sensory neurons are absent in the ventral zone and in some of the dorsal zone of the olfactory bulb epithelium
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• no expression of class II olfactory receptor genes in the dorsal or ventral zones of the olfactory epithelium
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growth/size/body
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• olfactory sensory neurons are absent in the ventral zone and in some of the dorsal zone of the olfactory bulb epithelium
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• no expression of class II olfactory receptor genes in the dorsal or ventral zones of the olfactory epithelium
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eno2tm1(DTA)Hsak mutation
(1 available);
any
Eno2 mutation
(53 available)
Tg(Nes-cre/ERT2)5-1Imayo mutation
(1 available)
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nervous system
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• 3 weeks following treatment with tamoxifen, mice exhibit ablation of newly formed neurons in the olfactory bulb that becomes more severe at 6 and 12 weeks of treatment
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• following treatment with tamoxifen, mice exhibit ablation of newly forming neurons
• following treatment with tamoxifen, neuroblasts at the entry site of the rostral migratory stream exhibit markers of apoptosis
• 3 weeks following treatment with tamoxifen, mice exhibit ablation of newly formed neurons in the olfactory bulb that becomes more severe at 6 and 12 weeks of treatment
• following treatment with tamoxifen, mice exhibit a loss of granule cells in deep regions while superficial neurons are preserved
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• 3 weeks following treatment with tamoxifen, mice exhibit loss of granule neurons in the olfactory bulb
• following treatment with tamoxifen, mice exhibit decreased granule cell density in the dentate gyrus compared to in wild-type mice
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behavior/neurological
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N |
• despite ablation of olfactory neurons, mice exhibit normal behavior towards wild-type mice and normal odor-associated memory
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eno2tm1(DTA)Hsak mutation
(1 available);
any
Eno2 mutation
(53 available)
Tg(Nes-cre/ERT2)4Imayo mutation
(1 available)
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nervous system
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• following treatment with tamoxifen, mice exhibit decreased granule cell density in the dentate gyrus instead of the increase observed in wild-type mice
• however, neuronal circuits in the dentate gyrus are normal
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• 3 weeks following treatment with tamoxifen, mice exhibit ablation of newly formed neurons in the olfactory bulb that becomes more severe at 6 and 12 weeks of treatment
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• following treatment with tamoxifen, mice exhibit ablation of newly forming neurons
• following treatment with tamoxifen, neuroblasts at the entry site of the rostral migratory stream exhibit markers of apoptosis
• 3 weeks following treatment with tamoxifen, mice exhibit ablation of newly formed neurons in the olfactory bulb that becomes more severe at 6 and 12 weeks of treatment
• following treatment with tamoxifen, mice exhibit a loss of granule cells in deep regions while superficial neurons are preserved
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• 3 weeks following treatment with tamoxifen, mice exhibit loss of granule neurons in the olfactory bulb
• following treatment with tamoxifen, mice exhibit decreased granule cell density in the dentate gyrus compared to in wild-type mice
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behavior/neurological
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N |
• despite ablation of olfactory neurons, mice exhibit normal behavior towards wild-type mice and normal odor-associated memory
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• tamoxifen treated mice exhibit reduced freezing responses compared to wild-type mice
• however, cue conditioning is normal
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• in a Barnes maze spatial memory test, tamoxifen treated mice exhibit impaired retention of spatial memory compared to wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eno2tm1(DTA)Hsak mutation
(1 available);
any
Eno2 mutation
(53 available)
Gng7tm2(cre/PGR)Mmsh mutation
(0 available);
any
Gng7 mutation
(75 available)
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Ablation of medium-spiny projection neurons in the striatum of Gng7tm2(cre/PGR)Mmsh/Gng7+ Eno2tm1(DTA)Hsak/Eno2+ mice
nervous system
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• strong TUNEL staining is seen in the caudate putamen, nucleus accumbens and olfactory tubercle 10 days after RU-486 injection
• 13 days after RU-486 injection the density of NeuN positive neurons is dramatically reduced in the caudate putamen and the number of NeuN positive neurons is reduced in the nucleus accumbens core and shell
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• lack calbindin positive neurons in the striatum after RU-486 treatment
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behavior/neurological
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N |
• despite ablation of striatal neurons, no defects in motor coordination are detected
• all behavioral phenotype data are from mice at 13 to 22 days after RU-486 treatment
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• treatment with RU-486 after long term memory formation and then testing for memory retention 14 days later shows an impairment in fear memory retention
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• impaired conditioning when using a low intensity unconditioned stimulus but not when using a higher intensity unconditioned stimulus
• impaired development of long term but not of short term fear memory when using a low intensity unconditioned stimulus
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• 14 days after RU-486 treatment
• reduced freezing response on 2nd day in conditioning chamber
• unconditioned stimulus is a foot shock
• if RU-486 treatment occurs more than 24 hours after the unconditioned stimulus, fear memory is unaffected
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• fail to show any improvement in performance over repeated trial on an accelerating rotarod
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• increase in activity in an open field assay
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cellular
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• strong TUNEL staining is seen in the caudate putamen, nucleus accumbens and olfactory tubercle 10 days after RU-486 injection
• 13 days after RU-486 injection the density of NeuN positive neurons is dramatically reduced in the caudate putamen and the number of NeuN positive neurons is reduced in the nucleus accumbens core and shell
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eno2tm1(DTA)Hsak mutation
(1 available);
any
Eno2 mutation
(53 available)
Tg(Gpr151-cre)#Ito mutation
(1 available)
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behavior/neurological
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N |
• mice exhibit normal performance in fear conditioning tests and saccharin preference
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• following systemic nicotine administration, mice fail to exhibit slowed down nose-poke reaction and enhanced adaptation unlike control mice
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• absence of habituation upon repeated exposure to a new environment
• however, exploration of a new environment is normal
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• in a corner avoidance test
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• poor spatial memory in a Morris water maze
• tendency to working memory deficits in a radial arm maze
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• modest in an open field test (reduced time in center area) and an elevated plus maze (reduced time in open arms)
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• premature response in a 5-choice serial reaction time task (5-CSRTT)
• in a T maze, mice exhibit devalued reward by delay and effort compared with control mice
• in a saccharin preference test, mice exhibit poorly controlled response to reward compared with control mice
• however, erroneous nose-pokes are normal indicating unaltered spatial attention
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• tendency during the early night period in the home cage
• visit hyperactivity in free, nose-poke and drinking adaptation tests
• however, exploration of a new environment is normal
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nervous system
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• reduced acetylcholine concentration in interpeduncular nucleus
• reduced interpeduncular nucleus volume not due to cell loss
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• mice exhibit reduced number of neurons, specifically substance P-nergic and cholinergic cells, in the habenular complex medial and lateral nuclei compared with control mice
• reduced transverse area of fasciculus retroflux
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• mice exhibit reduced number of neurons, specifically substance P-nergic and cholinergic cells, in the habenular complex medial and lateral nuclei compared with control mice
• reduced acetylcholine concentration in interpeduncular nucleus
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• mice exhibit reduced number of neurons, specifically substance P-nergic and cholinergic cells, in the habenular complex medial and lateral nuclei compared with control mice
• however, the number of neurons in the paraventricular and reuniens thalamic nuclei is normal
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