Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sarm1tm1Aidi mutation
(1 available);
any
Sarm1 mutation
(24 available)
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cellular
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• in response to oxygen and glucose deprivation, hippocampus cells exhibit reduced apoptosis (31.89+/-3.34% compared to 67.21+/-5.10% in wild-type cells)
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immune system
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N |
• macrophages exhibit normal function
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sarm1tm1Aidi mutation
(1 available);
any
Sarm1 mutation
(24 available)
Stmn2em1Jmi mutation
(0 available);
any
Stmn2 mutation
(41 available)
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behavior/neurological
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• at 3 months of age, mice show a decrease in the latency time (s) to fall from an inverted screen that is similar to that in single Stmn2em1Jmi homozygotes, indicating severe motor function impairment
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nervous system
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• lumbrical muscle NMJs exhibit presynaptic and postsynaptic elements that are indistinguishable from those of single Stmn2em1Jmi homozygotes, including endplate fragmentation and many regions of partial innervation
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Analysis Tools