Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation
(3 available);
any
Gabrg2 mutation
(41 available)
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mortality/aging
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• mice that are born die before P19
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behavior/neurological
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• mice that are born exhibit a severe tremor
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• mice that are born have altered gaits
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nervous system
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• mice lack normal brain rhythms
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Allelic
Composition |
Gabrg2tm1Spet/Gabrg2+
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Genetic
Background |
involves: 129 * BALB/cJ * C57BL/6 * DBA/2J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation
(3 available);
any
Gabrg2 mutation
(41 available)
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nervous system
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• Background Sensitivity: more mice (greater than 90%) exhibit symptomatic spike-wave discharge (SWD) on a DBA/2J background than on a C57BL/6 background with longer SWD episodes (2.53+/-0.21 ms compared to 1.20+/-0.16 ms on a C57BL/6 background)
• Background Sensitivity: paroxysmal discharges are first noted at P20, by P22 amplitudes of the sharp waves are increased with associated behavioral arrest and frank epileptiform discharges occur by P24 to P28 with distinct spikes and wave morphology associated with behavioral arrest
• treatment with ethosuximide (200 mg per kg) reduces absence seizure
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• miniature inhibitory postsynaptic current amplitudes of cortical neurons are lower than in wild-type mice (57.9+/-2.9 pA compared to 66.4+/-1.8 pA in wild-type mice)
• however, spontaneous inhibitory postsynaptic currents in the thalamic reticular nuclei are normal
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behavior/neurological
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• Background Sensitivity: more mice (greater than 90%) exhibit symptomatic spike-wave discharge (SWD) on a DBA/2J background than on a C57BL/6 background with longer SWD episodes (2.53+/-0.21 ms compared to 1.20+/-0.16 ms on a C57BL/6 background)
• Background Sensitivity: paroxysmal discharges are first noted at P20, by P22 amplitudes of the sharp waves are increased with associated behavioral arrest and frank epileptiform discharges occur by P24 to P28 with distinct spikes and wave morphology associated with behavioral arrest
• treatment with ethosuximide (200 mg per kg) reduces absence seizure
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Allelic
Composition |
Gabrg2tm1Spet/Gabrg2+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation
(3 available);
any
Gabrg2 mutation
(41 available)
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behavior/neurological
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• induced by pentylenetetrazil
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nervous system
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• induced by pentylenetetrazil
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Allelic
Composition |
Gabrg2tm1Spet/Gabrg2+
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|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation
(3 available);
any
Gabrg2 mutation
(41 available)
|
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nervous system
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• mice are more sensitive to seizures induced with 85 mg per kg pentylenetetrazol than wild-type mice
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• when stimulated with 5 and 8 Hz and high-amplitude (500 to 1100 uV) spike-wave discharge (SWD) is observed up to 50 times an hour
• during SWD mice pause and display stereotypical nodding and twitching of the orofacial region with some mice exhibiting subtle head jerk or turn that are not observed in wild-type mice
• Background Sensitivity: fewer mice exhibit symptomatic spike-wave discharge (SWD) on a C57BL/6 background than on a DBA/2J background with shorter SWD episodes (1.20+/-0.16 ms compared to 2.53+/-0.21 ms on DBA/2J background)
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• miniature inhibitory postsynaptic current amplitudes of cortical neurons are lower than in wild-type mice (58.4+/-2.2 pA compared to 67.5+/-2.9 pA in wild-type mice)
• however, spontaneous inhibitory postsynaptic currents in the thalamic reticular nuclei are normal
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behavior/neurological
|
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• mice are more sensitive to seizures induced with 85 mg per kg pentylenetetrazol than wild-type mice
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• when stimulated with 5 and 8 Hz and high-amplitude (500 to 1100 uV) spike-wave discharge (SWD) is observed up to 50 times an hour
• during SWD mice pause and display stereotypical nodding and twitching of the orofacial region with some mice exhibiting subtle head jerk or turn that are not observed in wild-type mice
• Background Sensitivity: fewer mice exhibit symptomatic spike-wave discharge (SWD) on a C57BL/6 background than on a DBA/2J background with shorter SWD episodes (1.20+/-0.16 ms compared to 2.53+/-0.21 ms on DBA/2J background)
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behavior/neurological
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• mild increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)
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nervous system
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• mild increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation
(3 available);
any
Gabrg2 mutation
(41 available)
n-TRtct5m1J mutation
(4 available);
any
n-TRtct5 mutation
(4 available)
Tg(n-TRtct5)574Slac mutation
(0 available)
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behavior/neurological
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• significant increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)
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nervous system
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• significant increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)
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Analysis Tools