Tg(n-TRtct5)574Slac
Transgene Detail

Summary

• Symbol: Tg(n-TRtct5)574Slac
• Name: transgene insertion 574, Susan L Ackerman
• MGI ID: MGI:5576570
• Synonyms: Tg(n-Tr20)574Slac, Tg(n-Tr20^B6N)574Slac, Tg(n-Tr20^N, Tg^wt
• Transgene: Tg(n-TRtct5)574Slac Location: unknown
• Alliance: Tg(n-TRtct5)574Slac page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(n-TRtct5)574Slac expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	n-TRtct5 (MGI:4413733)

• Mutation details: A 1.2 kb PCR fragment containing n-Tr20 was amplified from C57BL/6NJ genomic DNA and injected into pronuclei of C57BL/6J zygotes, thereby restoring expression of n-Tr20 in the C57BL/6J inbred, which has the n-Tr20 mutant allele. (J:211326)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:211326 Ishimura R, et al., RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Science. 2014 Jul 25;345(6195):455-9
• All: 5 reference(s)