Phenotypes associated with this allele

• Allele Symbol: Sln^tm1Peri
• Allele Name: targeted mutation 1, Muthu Periasamy
• Allele ID: MGI:3764910
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sln^tm1Peri/Sln^tm1Peri	involves: Black Swiss * C57BL/6	MGI:3764911
hm2	Sln^tm1Peri/Sln^tm1Peri	involves: C57BL/6J	MGI:6104242
cx3	Sln^tm1Peri/Sln^tm1Peri Ucp1^tm1Kz/Ucp1^tm1Kz	involves: 129S2/SvPas * C57BL/6J	MGI:6104243

Genotype
MGI:3764911

hm1

• Allelic Composition: Sln^tm1Peri/Sln^tm1Peri
• Genetic Background: involves: Black Swiss * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:127150 )

N • cardiac morphology and muscle structure is normal

increased cardiac muscle contractility ( J:127150 )

• the maximum rate of contraction is increased compared to wild-type mice

• however, time to peak pressure and half-relaxation pressure derived from intraventricular pressure tracings are normal

• at a low dose of isoproterenol, maximum rate of contraction is increased compared to in wild-type mice

• however, at high doses of isoproterenol mice exhibit the same maximum rate of contraction as wild-type mice

• under basal conditions the isometric force generated is 1.6 times that generated in wild-type atria and increased calcium fails to further increase the isometric force generated

• time taken for 50% relaxation and 90% relaxation are decreased compared to in wild-type atria

• unlike in wild-type atria, treatment of atria with isoproterenol does not affect isometric contraction

muscle

increased cardiac muscle contractility ( J:127150 )

• the maximum rate of contraction is increased compared to wild-type mice

• however, time to peak pressure and half-relaxation pressure derived from intraventricular pressure tracings are normal

• at a low dose of isoproterenol, maximum rate of contraction is increased compared to in wild-type mice

• however, at high doses of isoproterenol mice exhibit the same maximum rate of contraction as wild-type mice

• under basal conditions the isometric force generated is 1.6 times that generated in wild-type atria and increased calcium fails to further increase the isometric force generated

• time taken for 50% relaxation and 90% relaxation are decreased compared to in wild-type atria

• unlike in wild-type atria, treatment of atria with isoproterenol does not affect isometric contraction

Genotype
MGI:6104242

hm2

• Allelic Composition: Sln^tm1Peri/Sln^tm1Peri
• Genetic Background: involves: C57BL/6J

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:193427 )

• when fed a high-fat diet

impaired adaptive thermogenesis ( J:193427 )

• reduced body temperature when cold-exposed

• inability to maintain temperature and death due to hypothermia in cold-exposed mice with surgically ablated interscapular brown adipose tissue

increased circulating glucose level ( J:193427 )

• when fed a high-fat diet

increased circulating cholesterol level ( J:193427 )

• when fed a high-fat diet

increased circulating triglyceride level ( J:193427 )

• when fed a high-fat diet

decreased body temperature ( J:193427 )

• in cold exposed mice with or without interscapular brown adipose tissue

• in cold exposed acclimatized mice

decreased oxygen consumption ( J:193427 )

• in cold-exposed mice

impaired glucose tolerance ( J:193427 )

• when fed a high-fat diet

adipose tissue

increased body fat mass ( J:193427 )

• when fed a high-fat diet

increased brown fat cell lipid droplet size ( J:193427 )

• when fed a high-fat diet

increased white fat cell lipid droplet size ( J:193427 )

• when fed a high-fat diet

increased total fat pad weight ( J:193427 )

• when fed a high-fat diet

growth/size/body

increased body fat mass ( J:193427 )

• when fed a high-fat diet

increased susceptibility to diet-induced obesity ( J:193427 )

• when fed a high-fat diet

behavior/neurological

decreased food intake ( J:193427 )

• when fed a high-fat diet

liver/biliary system

hepatic steatosis ( J:193427 )

• when fed a high-fat diet

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:193427 )

• due to hypothermia in cold-exposed mice with surgically ablated interscapular brown adipose tissue

• however, transgenic expression of the gene rescues lethality

Genotype
MGI:6104243

cx3

• Allelic Composition: Sln^tm1Peri/Sln^tm1Peri; Ucp1^tm1Kz/Ucp1^tm1Kz
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

mortality/aging

prenatal lethality, incomplete penetrance ( J:193427 )

• fewer than expected mice are born