Phenotypes associated with this allele

• Allele Symbol: Prlhr^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3764478
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prlhr^tm1Dgen/Prlhr^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3764482

Genotype
MGI:3764482

hm1

• Allelic Composition: Prlhr^tm1Dgen/Prlhr^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:127335 )

• fasting glucose levels are increased in females (10.85+/-0.51 mM compared to 9.11+/-0.33 mM in wild-type females)

increased circulating corticosterone level ( J:127335 )

• female mice exhibit increased serum cortiosterone (517.48+/-36.83 ng/ml compared to 403.60+/-30.26 ng/ml in wild-type females)

increased circulating leptin level ( J:127335 )

• in both males and females (males, 3.72+/-0.07 mM compared to 3.17+/-0.13 mM in wild-type males)

increased cholesterol level ( J:127335 )

• in both males and females

increased circulating HDL cholesterol level ( J:127335 )

• in females but not males

increased circulating LDL cholesterol level ( J:127335 )

• in females but not males

growth/size/body

increased body weight ( J:127335 )

• beginning at weeks 11 and 15 mice exhibit increased body weight compared to wild-type mice

• at week 24, females are 21% and males 12% heavier than wild-type mice

increased body length ( J:127335 )

• at week 24, female mice exhibit increased body length (10.7+/-0.05 cm compared to 10.56+/-0.03 cm for wild-type mice)

adipose tissue

increased total body fat amount ( J:127335 )

• at 24 weeks, females have a 91% higher fat mass (10.50+/-1.38 g compared to 5.50+/-0.40 g for wild-type mice)

• at 24 weeks, males have a 39% higher fat mass (10.40+/-0.57g compared to 7.45+/-0.73 g for wild-type mice)

increased percent body fat/body weight ( J:127335 )

• males and females have an increased fat percentage

behavior/neurological

decreased food intake ( J:127335 )

• female mice exhibit a 25% decrease in food intake compared to wild-type mice (0.040+/-0.05 g food/g body weight compared to 0.54+/-0.04 g food/g body weight in wild-type female mice)