Phenotypes associated with this allele

• Allele Symbol: Tg(Alb-PLG)1Dgi
• Allele Name: transgene insertion 1, David Ginsburg
• Allele ID: MGI:3763545
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Plg^tm1Dco/Plg^tm1Dco Tg(Alb-PLG)1Dgi/0	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL	MGI:3839573
tg2	Tg(Alb-PLG)1Dgi/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:3839574

Genotype
MGI:3839573

cx1

• Allelic Composition: Plg^tm1Dco/Plg^tm1Dco; Tg(Alb-PLG)1Dgi/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:120780 )

N • LPS-treated mice exhibit normal mortality

digestive/alimentary system

rectal prolapse ( J:120780 )

• mice exhibit a near complete rescue of the rectal prolapse observed in Plg^tm1Dco homozygotes

growth/size/body

decreased body weight ( J:120780 )

• mice exhibit a near complete rescue of the decreased body weight observed in Plg^tm1Dco homozygotes

liver/biliary system

liver/biliary system phenotype ( J:120780 )

N • liver fibrosis observed in Plg^tm1Dco homozygotes is reversed

Genotype
MGI:3839574

tg2

• Allelic Composition: Tg(Alb-PLG)1Dgi/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:120780 )

• mice infected subcutaneously with the human pathogenic group A streptococcus (GAS) strain UMAA2616 exhibit 75% of mortality unlike similarly treated wild-type mice that exhibit 20% mortality

• mice infected subcutaneously with GAS strain MGAS166 exhibit 35% to 100% of mortality unlike similarly treated wild-type mice that exhibit 30% mortality

• however, mice exhibit normal mortality when infected with GAS strain UMAA2641, which lacks the Ska gene, or when infected intravenously with UMAA2616

• mice infected subcutaneously with PAM-expressing GAS strain AP53 exhibit 80% mortality compared to 20% in similarly treated wild-type mice

immune system

increased susceptibility to bacterial infection ( J:120780 )

• mice infected subcutaneously with the human pathogenic group A streptococcus (GAS) strain UMAA2616 exhibit 75% of mortality unlike similarly treated wild-type mice that exhibit 20% mortality

• mice infected subcutaneously with GAS strain MGAS166 exhibit 35% to 100% of mortality unlike similarly treated wild-type mice that exhibit 30% mortality

• however, mice exhibit normal mortality when infected with GAS strain UMAA2641, which lacks the Ska gene, or when infected intravenously with UMAA2616

• mice infected subcutaneously with PAM-expressing GAS strain AP53 exhibit 80% mortality compared to 20% in similarly treated wild-type mice

• mice infected subcutaneously with GAS exhibit increased bacterial colonies in the spleen compared to similarly infected wild-type mice