Phenotypes associated with this allele

• Allele Symbol: Mdm2^tm1Ypz
• Allele Name: targeted mutation 1, Yanping Zhang
• Allele ID: MGI:3763432
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm2^tm1Ypz/Mdm2^tm1Ypz	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3763435
cx2	Mdm2^tm1Ypz/Mdm2^tm1Ypz Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3763436
cx3	Mdm2^tm1Ypz/Mdm2^tm1Ypz Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3763437

Genotype
MGI:3763435

hm1

• Allelic Composition: Mdm2^tm1Ypz/Mdm2^tm1Ypz
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:126004 )

• mice die prior to E7.5

embryo

abnormal gastrulation ( J:126004 )

• embryos fail to undergo proper gastrulation

embryonic growth retardation ( J:126004 )

• at E7.5 embryos exhibit a size and structure similar to E6.5 embryos

decreased embryo size ( J:126004 )

• at E7.5

growth/size/body

embryonic growth retardation ( J:126004 )

• at E7.5 embryos exhibit a size and structure similar to E6.5 embryos

decreased embryo size ( J:126004 )

• at E7.5

Genotype
MGI:3763436

cx2

• Allelic Composition: Mdm2^tm1Ypz/Mdm2^tm1Ypz; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB/N

mortality/aging

postnatal lethality ( J:126004 )

• no mice are recovered at the time of genotyping

Genotype
MGI:3763437

cx3

• Allelic Composition: Mdm2^tm1Ypz/Mdm2^tm1Ypz; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB/N

mortality/aging

mortality/aging ( J:126004 )

N • embryonic lethality observed in Mdm2^tm1Ypz homozygotes is rescued