Phenotypes associated with this allele

• Allele Symbol: Ing1^{Gt(F066C08)Irpa}
• Allele Name: gene trap F066C08, Ignacio Palmero
• Allele ID: MGI:3762907
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ing1^Gt(F066C08)Irpa/Ing1^Gt(F066C08)Irpa	involves: 129S2/SvPas	MGI:3762908

Genotype
MGI:3762908

hm1

• Allelic Composition: Ing1^{Gt(F066C08)Irpa}/Ing1^{Gt(F066C08)Irpa}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:126798 )

N • despite altered response to Ras retroviral infection, mouse embryonic fibroblasts (MEFs) can enter replicative senescence and reach immortality at rates indistinguishable from wild-type MEFs and are as sensitive to apoptosis in thymocytes induced by DNA damage or other stimuli as wild-type MEFs

increased fibroblast proliferation ( J:126798 )

• mouse embryonic fibroblast cells (MEFs) are insensitive to infection with a retroviral Ras exhibiting an increase in proliferation relative to controls and decreased senescence unlike similarly treated wild-type MEFs

delayed cellular replicative senescence ( J:126798 )

• very few cells exhibit senescence when infection with a retroviral Ras unlike similarly treated wild-type MEFs