Ing1^{Gt(F066C08)Irpa}
Gene trapped Allele Detail

Summary

• Symbol: Ing1^{Gt(F066C08)Irpa}
• Name: inhibitor of growth family, member 1; gene trap F066C08, Ignacio Palmero
• MGI ID: MGI:3762907
• Synonyms: Ing1^Bgeo
• Gene: Ing1 Location: Chr8:11605762-11613251 bp, + strand Genetic Position: Chr8, 5.73 cM
• Alliance: Ing1^{Gt(F066C08)Irpa} page

Mutation origin

• Mutant Cell Line: F066C08
• Germline Transmission: Earliest citation of germline transmission: J:126798
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pT1ATGbetageo
• Mutation details: The gene trap vector pT1ATGbgeo was inserted into the intron between exons 1b and 1c 67 bp upstream of exon 1c. The shorter alternative transcript, p24, was not detected by western blot analysis on mouse embryonic fibroblast cells where as the longer transcript,p33, is expressed normally. (J:126798)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  F066C08	CL210875 ; (MGI Seq Detail)	5' RACE	Chr8:11606900-11607039 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  14 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ing1 Mutation: 25 strains or lines available

References

• Original: J:126798 Abad M, et al., Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress. J Biol Chem. 2007 Oct 19;282(42):31060-7
• All: 2 reference(s)