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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lgr4tm1.1Knis
targeted mutation 1.1, Katsuhiko Nishimori
MGI:3762639
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lgr4tm1.1Knis/Lgr4tm1.1Knis
Tg(KRT5-cre)1Tak/0 		involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL MGI:3762651
cn2
 		Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Cyp1a1-cre)1Dwi/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5285826
cn3
 		Lgr4tm1.1Knis/Lgr4tm1.1Knis
Tg(Cyp1a1-cre)1Dwi/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5285827
cn4
 		Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5285825


Genotype
MGI:3762651
cn1
Allelic
Composition		 Lgr4tm1.1Knis/Lgr4tm1.1Knis
Tg(KRT5-cre)1Tak/0
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr4tm1.1Knis mutation (0 available); any Lgr4 mutation (94 available)
Tg(KRT5-cre)1Tak mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:126813 )
N
• unlike mice homozygous for Lgr4tm1.2Knis no embryonic or neonatal lethality is detected

vision/eye
eyelids open at birth ( J:126813 )
• seen in all mutant mice

growth/size/body
growth/size/body region phenotype ( J:126813 )
N
• unlike mice homozygous for Lgr4tm1.2Knis body size and organ weights are normal




Genotype
MGI:5285826
cn2
Allelic
Composition		 Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr4tm1.1Knis mutation (0 available); any Lgr4 mutation (94 available)
Lgr5tm2.1Cle mutation (0 available); any Lgr5 mutation (57 available)
Tg(Cyp1a1-cre)1Dwi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:174842 )
• in beta-napthoflavone-treated mice

digestive/alimentary system
abnormal small intestinal crypt cell proliferation ( J:174842 )
• after 5 days, beta-napthoflavone-treated mice exhibit a loss of crypt width with loss of crypt stem cells and proliferating progenitors compared with control mice
• however, wild-type crypt stem cell escapers exhibit proliferation
decreased small intestinal villus size ( J:174842 )
• in beta-napthoflavone-treated mice

cellular
abnormal small intestinal crypt cell proliferation ( J:174842 )
• after 5 days, beta-napthoflavone-treated mice exhibit a loss of crypt width with loss of crypt stem cells and proliferating progenitors compared with control mice
• however, wild-type crypt stem cell escapers exhibit proliferation




Genotype
MGI:5285827
cn3
Allelic
Composition		 Lgr4tm1.1Knis/Lgr4tm1.1Knis
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr4tm1.1Knis mutation (0 available); any Lgr4 mutation (94 available)
Tg(Cyp1a1-cre)1Dwi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:174842 )
• in beta-napthoflavone-treated mice

digestive/alimentary system
abnormal small intestinal crypt cell proliferation ( J:174842 )
• beta-napthoflavone-treated mice exhibit a loss of crypt width with loss of crypt stem cells and proliferating progenitors compared with control mice
decreased small intestinal villus size ( J:174842 )
• in beta-napthoflavone-treated mice

cellular
abnormal small intestinal crypt cell proliferation ( J:174842 )
• beta-napthoflavone-treated mice exhibit a loss of crypt width with loss of crypt stem cells and proliferating progenitors compared with control mice




Genotype
MGI:5285825
cn4
Allelic
Composition		 Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr4tm1.1Knis mutation (0 available); any Lgr4 mutation (94 available)
Lgr5tm2.1Cle mutation (0 available); any Lgr5 mutation (57 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestine physiology ( J:174842 )
• generated intestinal organoids degrade after 2 days of tamoxifen treatment
• however, organoid survival is rescued by retroviral expression of LGR5




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory