All Phenotypes Lime1<tm1.1Mal> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lime1^tm1.1Mal
targeted mutation 1.1, Bernard Malissen
MGI:3762394

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lime1^tm1.1Mal/Lime1^tm1.1Mal	involves: 129S2/SvPas * C57BL/6	MGI:3762493
cx2	Lime1^tm1.1Mal/Lime1^tm1.1Mal Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)1Pas/?	B6.Cg-Rag2^tm1Fwa Lime1^tm1.1Mal Tg(TcraH-Y,TcrbH-Y)1Pas	MGI:3762494
cx3	Lat2^tm1Mal/Lat2^tm1Mal Lime1^tm1.1Mal/Lime1^tm1.1Mal	involves: 129 * C57BL/6	MGI:3762495
cx4	Lime1^tm1.1Mal/Lime1^tm1.1Mal Pag1^tm1Sbln/Pag1^tm1Sbln	involves: 129S2/SvPas	MGI:5301870

Allelic Composition	Lime1^tm1.1Mal/Lime1^tm1.1Mal
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lime1^tm1.1Mal mutation (1 available); any Lime1 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:126321 )

N	• No abnormal phenotype observed in the development, number, or physiology of B cells, T cells, and natural killer cells

Allelic Composition	Lime1^tm1.1Mal/Lime1^tm1.1Mal Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background	B6.Cg-Rag2^tm1Fwa Lime1^tm1.1Mal Tg(TcraH-Y,TcrbH-Y)1Pas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lime1^tm1.1Mal mutation (1 available); any Lime1 mutation (6 available)
Rag2^tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(TcraH-Y,TcrbH-Y)1Pas mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:126321 )

• 1.8 fold increase in clonotype positive cells in the thymus of female but not male mice

increased CD4-positive, alpha-beta T cell number ( J:126321 )

• 3 fold increase in clonotype CD4 T cells in female but not male mice

immune system

abnormal CD4-positive T cell differentiation ( J:126321 )

• 1.8 fold increase in clonotype positive cells in the thymus of female but not male mice

increased CD4-positive, alpha-beta T cell number ( J:126321 )

• 3 fold increase in clonotype CD4 T cells in female but not male mice

Allelic Composition	Lat2^tm1Mal/Lat2^tm1Mal Lime1^tm1.1Mal/Lime1^tm1.1Mal
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2^tm1Mal mutation (1 available); any Lat2 mutation (19 available)
Lime1^tm1.1Mal mutation (1 available); any Lime1 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased anti-nuclear antigen antibody level ( J:126321 )

• detectable in 5 of 7 individuals

Allelic Composition	Lime1^tm1.1Mal/Lime1^tm1.1Mal Pag1^tm1Sbln/Pag1^tm1Sbln
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lime1^tm1.1Mal mutation (1 available); any Lime1 mutation (6 available)
Pag1^tm1Sbln mutation (0 available); any Pag1 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:177766 )

• mice are viable and fertile

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