Analysis Tools
cellular
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• cultured oligodendrocytes expressing p35 are resistant to apoptosis induced by cytotoxic cytokines such as Tnfa and interferon gamma (Ifng) compared to wild-type oligodendrocytes
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immune system
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• progression of autoimmune encephalomyelitis (EAE) induced by immunization with rat MOG 35-55 peptide is inhibited in mice expressing transgenic p35; at 11-20 days after treatment, 5/10 transgenic animals display EAE with an average clinical severity of 1.5 compared to 1/12 wild-type mice that show EAE with clinical severity of 4.25
• in EAE lesions of transgenic mice expressing p35, oligodendrocyte apoptosis is prevented; only a few proteolipid protein positive cells are seen infiltrating the white matter of the spinal cord in EAE mice, and number of apoptotic oligodendrocytes in white matter is significantly lower in white matter compared to transgenic cre-expressing mice
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