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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

+
wild type
MGI:3762347

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Del(2Hoxd11-Hoxd13)29Ddu/+	involves: 129S2/SvPas	MGI:2178061
cx2	Evx2/Hoxd13^{tm5(Hoxd11/lacZ)Ddu}/Del(2Hoxd11-Hoxd13)29Ddu	involves: 129S2/SvPas	MGI:4940349
cx3	Evx2/Hoxd13^{tm5(Hoxd11/lacZ)Ddu}/Del(2Hoxd11-Hoxd13)29Ddu	involves: 129S2/SvPas	MGI:4940350
cx4	Del(2Hoxd11-Hoxd13)29Ddu/+ Hoxd13^Dyc/Hoxd13⁺	involves: 129S2/SvPas * BALB/c	MGI:4361285
cx5	Del(2Hoxd11-Hoxd13)29Ddu/+ Hoxd13^spdh/Hoxd13⁺	involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J	MGI:3802653
cx6	Del(2Hoxd11-Hoxd13)29Ddu/Hoxd^tm3Ddu	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:2178141

Allelic Composition	Del(2Hoxd11-Hoxd13)29Ddu/+
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available); any Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

brachydactyly ( J:153164 , J:36443 )

• in digits 2 and 5 (J:153164)

• in newborns, digits II and V are reduced in size (shortened) (J:36443)

ectrodactyly ( J:71694 )

• digit V and digit II are always affected to some degree, particularly in the front paws

polydactyly ( J:36443 )

• at birth

Allelic Composition	Evx2/Hoxd13^{tm5(Hoxd11/lacZ)Ddu}/Del(2Hoxd11-Hoxd13)29Ddu
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available); any Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available)
Evx2/Hoxd13^{tm5(Hoxd11/lacZ)Ddu} mutation (0 available); any Evx2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

brachyphalangia ( J:33879 )

• the second phalanges is reduced or absent compared to in wild-type mice

brachydactyly ( J:33879 )

• digits II and V are shorter than in wild-type mice due to a reduction or absence of the second phalanges

skeleton

brachyphalangia ( J:33879 )

• the second phalanges is reduced or absent compared to in wild-type mice

Allelic Composition	Evx2/Hoxd13^{tm5(Hoxd11/lacZ)Ddu}/Del(2Hoxd11-Hoxd13)29Ddu
Genetic Background	involves: 129S2/SvPas

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

brachyphalangia ( J:33879 )

• the second phalanges is reduced or absent compared to in wild-type mice

brachydactyly ( J:33879 )

• digits II and V are shorter than in wild-type mice due to a reduction or absence of the second phalanges

skeleton

brachyphalangia ( J:33879 )

• the second phalanges is reduced or absent compared to in wild-type mice

Allelic Composition	Del(2Hoxd11-Hoxd13)29Ddu/+ Hoxd13^Dyc/Hoxd13⁺
Genetic Background	involves: 129S2/SvPas * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available); any Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available)
Hoxd13^Dyc mutation (1 available); any Hoxd13 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

brachydactyly ( J:153164 )

• in all digits

polydactyly ( J:153164 )

• in the hind limbs

polysyndactyly ( J:153164 )

• rare

Allelic Composition	Del(2Hoxd11-Hoxd13)29Ddu/+ Hoxd13^spdh/Hoxd13⁺
Genetic Background	involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available); any Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available)
Hoxd13^spdh mutation (1 available); any Hoxd13 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

ectrodactyly ( J:71694 )

• less pronounced than in homozygotes of either component mutation

polydactyly ( J:71694 )

• variable syndactyly of digits III and IV, along with a supernumerary digit in between

syndactyly ( J:71694 )

abnormal digit development ( J:71694 )

reproductive system

reduced male fertility ( J:71694 )

• although males homozygous for either mutation are sterile, approximately 60% of these trans-heterozygotes are fertile

skeleton

delayed endochondral bone ossification ( J:71694 )

• at 8 days of age the paws have some delay in the ossification process although ossification centers are observed

Allelic Composition	Del(2Hoxd11-Hoxd13)29Ddu/Hoxd^tm3Ddu
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available); any Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available)
Hoxd^tm3Ddu mutation (0 available); any Hoxd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:47900 )

• reductions in size of digits II and V

polydactyly ( J:47900 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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