Phenotypes associated with this allele

• Allele Symbol: Tg(Drd1a-cre)AGsc
• Allele Name: transgene insertion A, Gunther Schutz
• Allele ID: MGI:3761818
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Drd1a-cre)AGsc/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3852119
cn2	Drd2^tm3.1Ebo/Drd2^tm3.1Ebo Tg(Drd1a-cre)AGsc/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:5431883
cn3	Chrm4^tm2.1Jwe/Chrm4^tm2.1Jwe Tg(Drd1a-cre)AGsc/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4442324

Genotype
MGI:3852119

cn1

• Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc; Tg(Drd1a-cre)AGsc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:150544 )

N • Anxiety-related behavior, basic motor processes (movement, coordination), and associative learning are not impaired in mutants

abnormal behavioral response to addictive substance ( J:150544 )

• mice show profoundly decreased cocaine self-administration; acquistion of cocaine self-administration is similar to controls but dose-response is decreased indicating a lower reinforcing efficacy of cocaine

nervous system

abnormal nervous system electrophysiology ( J:150544 )

• spontaneous firing rate of dopamine neurons is highly reduced in ventral tegmental area (VTA)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:150544 )

N • circulating glucocorticoid levels are normal under basal and stress conditions

N • anxiety-related behaviors are not altered compared to controls indicating behavioral changes are specific to cocaine reinforcement

Genotype
MGI:5431883

cn2

• Allelic Composition: Drd2^tm3.1Ebo/Drd2^tm3.1Ebo; Tg(Drd1a-cre)AGsc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

behavior/neurological

impaired behavioral response to cocaine ( J:185643 )

• mice treated with cocaine exhibit a blunted hyperactivity response compared with control mice

impaired behavioral response to anesthetic ( J:185643 )

• mice fail to exhibit catalepsy induced by haloperidol compared with control mice

impaired coordination ( J:185643 )

• on a rotarod

decreased locomotor activity ( J:185643 )

• in the home cage and open field

• in mice fed cocaine

nervous system

nervous system phenotype ( J:185643 )

N • mice exhibit normal dopamine levels

abnormal nervous system electrophysiology ( J:185643 )

• neurons exhibit smaller relative peak amplitudes compared with control neurons

homeostasis/metabolism

abnormal dopamine level ( J:185643 )

• dopamine overflow evoked by a single stimulus in the dorsal striatum (DSt) is decreased compared to in control mice

• quinpirole-treated mice exhibit attenuated inhibition of dopamine overflow compared with control mice

• mice exhibit lower AMP evoked dopamine release compared with control mice

• however, mice exhibit normal dopamine reuptake

decreased physiological sensitivity to xenobiotic ( J:185643 )

• mice fail to exhibit catalepsy induced by haloperidol compared with control mice

• mice treated with quinpirole exhibit less of a decreased in locomotion compared with control mice

Genotype
MGI:4442324

cn3

• Allelic Composition: Chrm4^tm2.1Jwe/Chrm4^tm2.1Jwe; Tg(Drd1a-cre)AGsc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

nervous system

abnormal neuron physiology ( J:157841 )

• the inhibitory effect of carbachol, a hydrolytically stable ACh analog, is not observed in striatal membranes exposed to the D1 receptor agonist, SKF82958.

behavior/neurological

enhanced behavioral response to xenobiotic ( J:157841 )

• enhanced activity at the highest dose (30 ug/kg) of SKF82958, a D1 receptor agonist

enhanced behavioral response to addictive substance ( J:157841 )

• significantly more active following a high dose (2 mg/kg) of amphetamine

• develop enhanced amphetamine induced behavioral sensitization

enhanced behavioral response to cocaine ( J:157841 )

• significantly more active following exposure to a high dose (10 mg/kg) of cocaine

• develop enhanced cocaine induced behavioral sensitization

impaired behavioral response to xenobiotic ( J:157841 )

• haloperidol induced and risperidone induced catalepsy are attenuated

hyperactivity ( J:157841 )

• enhanced activity at the highest dose of SKF82958, a D1 receptor agonist

• enhanced activity at high doses of cocaine (10 mg/kg) or amphetamine (2 mg/kg)

catalepsy ( J:157841 )

• haloperidol induced and risperidone induced catalepsy are attenuated

homeostasis/metabolism

increased dopamine level ( J:157841 )

• basal dopamine efflux in the nucleus accumbens of is increased two- to three-fold

• absolute amphetamine-induced dopamine efflux was significantly enhanced at the 120 min time point, as compared to control mice

• however, the relative percent increase induced by amphetamine exposure is not different from controls