Chrm4^tm2.1Jwe
Targeted Allele Detail

Summary

• Symbol: Chrm4^tm2.1Jwe
• Name: cholinergic receptor, muscarinic 4; targeted mutation 2.1, Jurgen Wess
• MGI ID: MGI:4442323
• Gene: Chrm4 Location: Chr2:91757594-91759033 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Chrm4^tm2.1Jwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157841
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP and FRT flanked neo cassette was inserted 5' and a third loxP site was inserted 3' of the coding sequence via homologous recombination. The selection cassette was removed by flp mediated recombination leaving the entire coding sequence floxed. (J:157841)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm4 Mutation: 33 strains or lines available

References

• Original: J:157841 Jeon J, et al., A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. J Neurosci. 2010 Feb 10;30(6):2396-405
• All: 7 reference(s)