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Allele Symbol Allele Name Allele ID |
Foxn1tm3(cre)Nrm targeted mutation 3, Nancy R Manley MGI:3760775 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• absolute numbers of double negative cells in the thymus is increased 2-fold compared to in Dll4tm1Frad homozygous control mice
• only CD4+CD25- DN1 cells are present and these DN cells are B220+ unlike in control mice
• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in control mice
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• thymi exhibit a 14-fold reduction in the number of thymocytes compared to in Dll4tm1Frad homozygous control mice
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• the absolute numbers of immature B cells in the thymus are increased 340-fold compared to in Dll4tm1Frad homozygous control mice
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• T cells differentiated in the thymus is nearly completely blocked unlike in Dll4tm1Frad homozygous control mice
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• flow cytometry indicates a near complete loss of double positive T cells in the thymus
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• flow cytometry indicates a near complete loss of CD4+ T cells in the thymus
• absolute numbers of CD4+ T cells is reduced 180- to 3000-fold compared to Dll4tm1Frad homozygous in control mice
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• flow cytometry indicates a near complete loss of CD8+ T cells in the thymus
• absolute numbers of CD8+ T cells is reduced 180- to 3000-fold compared to in Dll4tm1Frad homozygous control mice
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• absolute numbers of double negative cells in the thymus is increased 2-fold compared to in Dll4tm1Frad homozygous control mice
• only CD4+CD25- DN1 cells are present and these DN cells are B220+ unlike in control mice
• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in control mice
|
|
• thymi exhibit a 14-fold reduction in the number of thymocytes compared to in Dll4tm1Frad homozygous control mice
|
|
• the absolute numbers of immature B cells in the thymus are increased 340-fold compared to in Dll4tm1Frad homozygous control mice
|
|
• T cells differentiated in the thymus is nearly completely blocked unlike in Dll4tm1Frad homozygous control mice
|
|
• flow cytometry indicates a near complete loss of double positive T cells in the thymus
|
|
• flow cytometry indicates a near complete loss of CD4+ T cells in the thymus
• absolute numbers of CD4+ T cells is reduced 180- to 3000-fold compared to Dll4tm1Frad homozygous in control mice
|
|
• flow cytometry indicates a near complete loss of CD8+ T cells in the thymus
• absolute numbers of CD8+ T cells is reduced 180- to 3000-fold compared to in Dll4tm1Frad homozygous control mice
|
|
• absolute numbers of double negative cells in the thymus is increased 2-fold compared to in Dll4tm1Frad homozygous control mice
• only CD4+CD25- DN1 cells are present and these DN cells are B220+ unlike in control mice
• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in control mice
|
|
• thymi exhibit a 14-fold reduction in the number of thymocytes compared to in Dll4tm1Frad homozygous control mice
|
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mice treated with pIpC
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• in mice treated with pIpC
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• in mice treated with pIpC
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• in mice treated with pIpC
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• in mice treated with pIpC
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• in mice treated with pIpC
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• in mice treated with pIpC
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• in mice treated with pIpC
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• in mice treated with pIpC
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• in the absence of tamoxifen no thymus abnormalities are detected
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• treatment with tamoxifen at 12 and 24 months of age reverses thymus involution as measured by increase in thymus size and thymocyte numbers, and the presence of clearly defined cortical and medullary regions
• increase in the proliferation of thymic epithelial cells in mice treated at 12 and 24 months of age with tamoxifen compared to age matched controls
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• treatment with tamoxifen at 12 and 24 months of age reverses thymus involution as measured by increase in thymus size and thymocyte numbers, and the presence of clearly defined cortical and medullary regions
• increase in the proliferation of thymic epithelial cells in mice treated at 12 and 24 months of age with tamoxifen compared to age matched controls
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• increase in the number of naive T cells in the peripheral immune system in mice treated at 12 and 24 months of age with tamoxifen compared to age matched controls
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• treatment with tamoxifen at 12 and 24 months of age reverses thymus involution as measured by increase in thymus size and thymocyte numbers, and the presence of clearly defined cortical and medullary regions
• increase in the proliferation of thymic epithelial cells in mice treated at 12 and 24 months of age with tamoxifen compared to age matched controls
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• increase in the number of naive T cells in the peripheral immune system in mice treated at 12 and 24 months of age with tamoxifen compared to age matched controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• progressive disruption of thymic architecture, which is apparent by 1 week of age
• the thymus appears disorganized at 1 week of age
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• progressive loss of the epithelium
• by 3 weeks of age large epithelial voids are present in the cortex and the medullary epithelium is almost absent
• epithelial cells are skewed toward immature stages
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• by 3 weeks large epithelial voids are present in the cortex
• thymocytes, macrophages and dense foci of CD19 + B cells are present in the epithelial voids
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• by 3 weeks the medullary epithelium is almost absent
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• increased proliferation and apoptosis of the epithelium
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• rapid premature involution with thymus size reduced by about 90% at 12 weeks of age
• castration does not eliminate premature involution
• unlike in wild-type mice, a low dose of poly I:C induces rapid involution
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• at 3 weeks of age fewer CD3 + CD69 + CD4 + CD8 + double-positive thymocytes are present after positive selection
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• in the periphery at 3 weeks of age
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• in the periphery at 3 weeks of age
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• increased susceptibility (increased incidence) to collagen-induced arthritis but a lower severity of disease (reduced mean maximal disease score)
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• progressive disruption of thymic architecture, which is apparent by 1 week of age
• the thymus appears disorganized at 1 week of age
|
|
• progressive loss of the epithelium
• by 3 weeks of age large epithelial voids are present in the cortex and the medullary epithelium is almost absent
• epithelial cells are skewed toward immature stages
|
|
• by 3 weeks large epithelial voids are present in the cortex
• thymocytes, macrophages and dense foci of CD19 + B cells are present in the epithelial voids
|
|
• by 3 weeks the medullary epithelium is almost absent
|
|
• increased proliferation and apoptosis of the epithelium
|
|
• rapid premature involution with thymus size reduced by about 90% at 12 weeks of age
• castration does not eliminate premature involution
• unlike in wild-type mice, a low dose of poly I:C induces rapid involution
|
|
• at 3 weeks of age fewer CD3 + CD69 + CD4 + CD8 + double-positive thymocytes are present after positive selection
|
|
• in the periphery at 3 weeks of age
|
|
• in the periphery at 3 weeks of age
|
|
• increased susceptibility (increased incidence) to collagen-induced arthritis but a lower severity of disease (reduced mean maximal disease score)
|
|
• progressive disruption of thymic architecture, which is apparent by 1 week of age
• the thymus appears disorganized at 1 week of age
|
|
• progressive loss of the epithelium
• by 3 weeks of age large epithelial voids are present in the cortex and the medullary epithelium is almost absent
• epithelial cells are skewed toward immature stages
|
|
• by 3 weeks large epithelial voids are present in the cortex
• thymocytes, macrophages and dense foci of CD19 + B cells are present in the epithelial voids
|
|
• by 3 weeks the medullary epithelium is almost absent
|
|
• increased proliferation and apoptosis of the epithelium
|
|
• rapid premature involution with thymus size reduced by about 90% at 12 weeks of age
• castration does not eliminate premature involution
• unlike in wild-type mice, a low dose of poly I:C induces rapid involution
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• mice remain healthy with no signs of abnormal immune system morphology, T cell activation, tissue pathology or wasting disease
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• proliferation in the GCM2-negative thymus-fated domain of the 3rd pharyngeal pouch is reduced at E11.5
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• marker analysis at E15.5 indicates an early block in thymic epithelial cell differentiation, with impaired differentiation of both cortical thymic epithelial cell and medullary thymic epithelial cell lineages and an accumulation of early thymic epithelial cell progenitors
• thymocytes show a partial block at the DN3 to DN4 transition at E15.5 indicating a partial differentiation arrest at the DN3 stage
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• accumulation of early thymic epithelial cell progenitors
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• fetal thymi are severely hypoplastic throughout development and remain so in the postnatal period
|
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• total thymocyte cellularity is decreased by about 5-fold in E15.5 thymi
|
|
• marker analysis at E15.5 indicates an early block in thymic epithelial cell differentiation, with impaired differentiation of both cortical thymic epithelial cell and medullary thymic epithelial cell lineages and an accumulation of early thymic epithelial cell progenitors
• thymocytes show a partial block at the DN3 to DN4 transition at E15.5 indicating a partial differentiation arrest at the DN3 stage
|
|
• accumulation of early thymic epithelial cell progenitors
|
|
• fetal thymi are severely hypoplastic throughout development and remain so in the postnatal period
|
|
• total thymocyte cellularity is decreased by about 5-fold in E15.5 thymi
|
|
• marker analysis at E15.5 indicates an early block in thymic epithelial cell differentiation, with impaired differentiation of both cortical thymic epithelial cell and medullary thymic epithelial cell lineages and an accumulation of early thymic epithelial cell progenitors
• thymocytes show a partial block at the DN3 to DN4 transition at E15.5 indicating a partial differentiation arrest at the DN3 stage
|
|
• accumulation of early thymic epithelial cell progenitors
|
|
• fetal thymi are severely hypoplastic throughout development and remain so in the postnatal period
|
|
• total thymocyte cellularity is decreased by about 5-fold in E15.5 thymi
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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