Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnx1tm4(cre)Tmj mutation
(2 available);
any
Mnx1 mutation
(28 available)
Mycbp2tm1Adia mutation
(0 available);
any
Mycbp2 mutation
(223 available)
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mortality/aging
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• some mice are stillborn while others survive into adulthood and are fertile
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nervous system
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• mice exhibit neurofilament-rich sprouts that extend beyond normally innervated endplates
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respiratory system
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• diaphragms exhibit full innervation unlike in Phr1tm1.1Adia homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation
(2 available);
any
Emx1 mutation
(34 available)
Mycbp2tm1Adia mutation
(0 available);
any
Mycbp2 mutation
(223 available)
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nervous system
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• authors state that mice exhibit the same axonal guidance defects as observed in Phr1tm1.1Adia homozygotes
• mice exhibit a track running through the internal capsule and retrogradely labeled cell bodies in the thalamus that is not observed in Phr1tm1.1Adia homozygotes
• at E14.5 and E15.5, cortical axons fail to cross the corticostriatal boundary terminating in a bulb reminiscent of Probst bundle
• however, there is no delay in cortical axon outgrowth
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• mice exhibit enlarged lateral ventricles
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• collasal axons from the incipient visual cortex never cross into the corpus callosum as they do in wild-type mice, instead they extend anteriorly and medially to terminate in large bulbs known as Probst bundles
• descending corticofugal axons contribute to a thinner than normal corpus callosum
• however, corticofugal projections in the internal capsule do not contribute to the internal capsule
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• mice exhibit narrower corpus callosum comapred to in wild-type mice
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• hippocampal formations are reduced in size and dysmorphic compared to in wild-type mice
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cellular
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• authors state that mice exhibit the same axonal guidance defects as observed in Phr1tm1.1Adia homozygotes
• mice exhibit a track running through the internal capsule and retrogradely labeled cell bodies in the thalamus that is not observed in Phr1tm1.1Adia homozygotes
• at E14.5 and E15.5, cortical axons fail to cross the corticostriatal boundary terminating in a bulb reminiscent of Probst bundle
• however, there is no delay in cortical axon outgrowth
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Analysis Tools