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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CD74)AR194Ayr
transgene insertion AR194, Alexander Y Rudensky
MGI:3760406
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cd74tm1Liz/Cd74tm1Liz
H2-DMatm1Luc/H2-DMatm1Luc
Tg(CD74)AR194Ayr/? 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J MGI:3760430
tg2
 		Tg(CD74)AR194Ayr/? B6.Cg-Tg(CD74)AR194Ayr MGI:3760408


Genotype
MGI:3760430
cx1
Allelic
Composition		 Cd74tm1Liz/Cd74tm1Liz
H2-DMatm1Luc/H2-DMatm1Luc
Tg(CD74)AR194Ayr/?
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Liz mutation (4 available); any Cd74 mutation (33 available)
H2-DMatm1Luc mutation (1 available); any H2-DMa mutation (27 available)
Tg(CD74)AR194Ayr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:88717 )
• the number of CD4+ T cells is reduced to levels below wild-type but similar to those observed in Cd74tm1Liz H2-DMatm1Luc homozygotes
abnormal antigen presentation via MHC class II ( J:88717 )
• unlike in wild-type cells, splenocytes are unable to elicit presentation of MHC class II exogenous antigens or of two endogenous antigens (IgM and beta-2 microglobulin)
• however, Tg(CD74)AR194Ayr completely rescues the MHC class II peptide loading observed in Cd74tm1Liz H2-DMatm1Luc homozygotes and presentation of endogenous antigens for CD22 is normal
• after incubation with Ealpha peptide, loading of MHC class II is less than on similarly treated Cd74tm1Liz H2-DMatm1Luc Tg(CD74*)AR194Ayr splenocytes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:88717 )
• the number of CD4+ T cells is reduced to levels below wild-type but similar to those observed in Cd74tm1Liz H2-DMatm1Luc homozygotes




Genotype
MGI:3760408
tg2
Allelic
Composition		 Tg(CD74)AR194Ayr/?
Genetic
Background		 B6.Cg-Tg(CD74)AR194Ayr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD74)AR194Ayr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:88717 )
• hemizygotes are viable and fertile and do not display any gross physical or behavioral abnormalities
• when crossed with invariant chain targeted mice, they act as controls for other human invariant chain mutant transgenic lines




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory