Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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immune system
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• following infection with Aspergillus fumigatus or Leishmania major, mice exhibit fewer IL-4 and IL-5 producing cells, slightly less acetylcholine reactivity and reduced serum levels of IgE compared to wild-type mice
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• after 5 days in culture, CD4+ T cells stimulated under TH2 conditions (phorbol 12-myristate 13-acetate and ionomycin) produce less IL-13 compared to wild-type cells
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• after 4 days in culture, CD4+ T cells stimulated under TH2 conditions (phorbol 12-myristate 13-acetate and ionomycin) produce less IL-4 and exhibit fewer IL-4 producing cells compared to wild-type cells
• after 5 days in culture, CD4+ T cells stimulated under TH2 conditions (phorbol 12-myristate 13-acetate and ionomycin) produce less IL-4 compared to wild-type cells
• however, proliferation and cytokine production of T cells under TH1 conditions and IL-4 production by mast cells stimulated with ionomycin are normal
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• after 5 days in culture, CD4+ T cells stimulated under TH2 conditions (phorbol 12-myristate 13-acetate and ionomycin) produce less IL-5 compared to wild-type cells
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• following infection with Nippostrongylus brasiliensis, mice contain fewer IL-4 producing cells compared to wild-type mice
• following infection with Aspergillus fumigatus or Leishmania major, mice exhibit fewer IL-4 and IL-5 producing cells, slightly less acetylcholine reactivity and reduced serum levels of IgE compared to wild-type mice
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• following infection with Leishmania major, mice exhibit reduced size of footpad lesions and fewer parasites are recovered from infected tissue compared to in wild-type mice
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hematopoietic system
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• following infection with Aspergillus fumigatus or Leishmania major, mice exhibit fewer IL-4 and IL-5 producing cells, slightly less acetylcholine reactivity and reduced serum levels of IgE compared to wild-type mice
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Allelic
Composition |
Rr250409tm1Lky/Rr250409+
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Genetic
Background |
involves: 129X1/SvJ * BALB/c * C57BL/6 * FVB |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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immune system
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• after 4 days in culture, CD4+ T cells stimulated under TH2 conditions (phorbol 12-myristate 13-acetate and ionomycin) produce less IL-4 than wild-type cells but more than cells homozygous for the Cigs1tm1Lky allele
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Analysis Tools