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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk8ip2tm1Rjd
targeted mutation 1, Roger J Davis
MGI:3759989
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd involves: 129X1/SvJ * C57BL/6 MGI:3759993
cx2
 		Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd
Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd 		involves: 129S6/SvEvTac * 129X1/SvJ MGI:4360031
cx3
 		Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd
Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:3759994
cx4
 		Mapk8ip1tm2.1Rjd/Mapk8ip1tm2.1Rjd
Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:4360034


Genotype
MGI:3759993
hm1
Allelic
Composition		 Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8ip2tm1Rjd mutation (0 available); any Mapk8ip2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

nervous system
abnormal NMDA-mediated synaptic currents ( J:125318 )
• NMDA-mediated current amplitude is decreased relative to in wild-type mice

growth/size/body
decreased body size ( J:125318 )




Genotype
MGI:4360031
cx2
Allelic
Composition		 Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd
Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8ip1tm1Rjd mutation (2 available); any Mapk8ip1 mutation (33 available)
Mapk8ip2tm1Rjd mutation (0 available); any Mapk8ip2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:152617 )
• within 2 weeks of birth

growth/size/body
growth/size/body region phenotype ( J:152617 )
N
• mice exhibit normal growth
decreased body size ( J:152617 )
• at P2 and P10
decreased body weight ( J:152617 )
• at P10
postnatal growth retardation ( J:152617 )
• severe

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:152617 )
N
• despite abnormal beta cell morphology, mice exhibit normal blood insulin concentration

endocrine/exocrine glands
abnormal pancreatic beta cell morphology ( J:152617 )
• beta cells exhibit fewer exocytotic vesicles compared with wild-type cells




Genotype
MGI:3759994
cx3
Allelic
Composition		 Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd
Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8ip1tm1Rjd mutation (2 available); any Mapk8ip1 mutation (33 available)
Mapk8ip2tm1Rjd mutation (0 available); any Mapk8ip2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellum morphology ( J:125318 )
• mice exhibit defects in the cerebellum
abnormal Purkinje cell morphology ( J:125318 )
• mice have defects in arborization of Purkinje cell
• however, cortical and hippocampal neurons are normal
abnormal NMDA-mediated synaptic currents ( J:125318 )
• treatment with NMDA fails to cause an increase in cytoplasmic calcium in neurons unlike in wild-type mice
• NMDA-mediated current amplitude is decreased relative to in wild-type mice
• desensitization of the NMDA-mediated current is reduced relative to in wild-type mice
• however, intracellular calcium homeostasis is normal

behavior/neurological
ataxia ( J:125318 )
• mice are severely ataxic




Genotype
MGI:4360034
cx4
Allelic
Composition		 Mapk8ip1tm2.1Rjd/Mapk8ip1tm2.1Rjd
Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8ip1tm2.1Rjd mutation (1 available); any Mapk8ip1 mutation (33 available)
Mapk8ip2tm1Rjd mutation (0 available); any Mapk8ip2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:152617 )
N
• mice exhibit normal growth




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory