Mapk8ip1^tm1Rjd
Targeted Allele Detail

Summary

• Symbol: Mapk8ip1^tm1Rjd
• Name: mitogen-activated protein kinase 8 interacting protein 1; targeted mutation 1, Roger J Davis
• MGI ID: MGI:2183313
• Synonyms: Jip1^-
• Gene: Mapk8ip1 Location: Chr2:92214021-92231608 bp, - strand Genetic Position: Chr2, 50.99 cM, cytoband E1
• Alliance: Mapk8ip1^tm1Rjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77616
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, encoding the JNK-binding domain, was replaced with a neomycin selection cassette. Western blot analysis of brain tissue showed an absence of encoded protein in homozygous mutant mice. (J:77616)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mapk8ip1 Mutation: 33 strains or lines available

References

• Original: J:77616 Whitmarsh AJ, et al., Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev. 2001 Sep 15;15(18):2421-32
• All: 7 reference(s)