Phenotypes associated with this allele

• Allele Symbol: Gab1^tm5Wbm
• Allele Name: targeted mutation 5, Walter Birchmeier
• Allele ID: MGI:3759868
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gab1^tm5Wbm/Gab1^tm5Wbm	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	MGI:3759965

Genotype
MGI:3759965

hm1

• Allelic Composition: Gab1^tm5Wbm/Gab1^tm5Wbm
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Placenta development and muscle progenitor cell migration are disturbed in Gab1^tm5Wbm/Gab1^tm5Wbm mice

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:125303 )

• mice only survive up to E12 when they are present in reduced ratios

embryo

thin placenta labyrinth ( J:125303 )

• at E12.5, placental labyrinth is 40% thinner than in wild-type mice

• however, the spongiotrophoblast layer is well developed

disorganized placental labyrinth ( J:125303 )

• at E12.5, placental labyrinth appears less organized

cellular

abnormal cell migration ( J:125303 )

• at E10.5, migratory cells in the limb bud or the hypoglossal stream are reduced compared to in wild-type mice

muscle

abnormal myogenesis ( J:125303 )

• muscle progenitor cells are 3 times less abundant and do not move as far distally as in wild-type mice

abnormal muscle precursor cell morphology ( J:125303 )

• muscle progenitor cells are 3 times less abundant and do not move as far distally as in wild-type mice

• at E12.5, muscle precursor cells are reduced in number relative to in wild-type mice