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| Caption | A-E: Analysis of placenta stage E12.5. Paraffin sections were prepared from placentas of wild type (Gab1 wt/wt) (A and D) and Gab1tm5Wbm/Gab1tm5Wbm (deltaShp2/deltaShp2) (B and E) mice. In situ hybridizations were carried out with the dlx3 probe (A and B), a marker for trophoblast cells of the labyrinth layer (Lb), and with the flt1 probe (D and E), a marker for the spongiotrophoblast layer (Sp). For quantification, the area fractions of labyrinth layer or spongiotrophoblast layer were compared with the corresponding areas of wild type placenta. There was a significant difference in the size of the labyrinth layers (*, P<0.05) (C). Whole-mount in situ hybridization of stage E10.5 embryos with an lbx1-specific probe of wild type ( F and I) and mutant (G and J) mice. Arrows mark myogenic progenitor cells in the limb buds. The arrowhead marks the hypoglossal stream of cells that migrated into the branchial arches (F and G). Vibratone transverse sections at forelimb level reveal reduced lbx1 staining in the limb buds of mutant mice (H-J). For quantifications, lbx1-positive areas were measured in corresponding limb sections. **, P<0.001. Scale bar 0.5mm. | ||||
| Copyright | This image is from Schaeper U, Proc Natl Acad Sci U S A 2007 Sep 25;104(39):15376-81. Copyright 2007 National Academy of Sciences, U.S.A. J:125303 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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