All Phenotypes Gab1<tm3Wbm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gab1^tm3Wbm
targeted mutation 3, Walter Birchmeier
MGI:3759864

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gab1^tm3Wbm/Gab1^tm3Wbm	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	MGI:3759967
ht2	Gab1^tm2Wbm/Gab1^tm3Wbm	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	MGI:3759968
cx3	Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met⁺	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	MGI:3759969

Allelic Composition	Gab1^tm3Wbm/Gab1^tm3Wbm
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1^tm3Wbm mutation (0 available); any Gab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Placenta defect and small liver size in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm and Gab1^tm2WbmGab1^tm3Wbm mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:125303 )

• mice live up to E16 but are never born

embryo

thin placenta labyrinth ( J:125303 )

• at E14.5, the labyrinth layer is half the thickness of wild-type labyrinth layers

disorganized placental labyrinth ( J:125303 )

• mice develop a disorganized labyrinth layer

liver/biliary system

decreased liver weight ( J:125303 )

• at E14.5, the liver to body weight ratio is 5.5% compared to 8% in wild-type mice

craniofacial

palatal shelves fail to meet at midline ( J:125303 )

cleft secondary palate ( J:125303 )

• at E16, the secondary palate remains open in one third of mice

muscle

muscle phenotype ( J:125303 )

N	• unlike mice with other altered Gab1 alleles, emigration of muscle progenitors is comparable to in wild-type mice and limbs form normally

digestive/alimentary system

palatal shelves fail to meet at midline ( J:125303 )

cleft secondary palate ( J:125303 )

• at E16, the secondary palate remains open in one third of mice

growth/size/body

palatal shelves fail to meet at midline ( J:125303 )

cleft secondary palate ( J:125303 )

• at E16, the secondary palate remains open in one third of mice

Allelic Composition	Gab1^tm2Wbm/Gab1^tm3Wbm
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1^tm2Wbm mutation (0 available); any Gab1 mutation (78 available)
Gab1^tm3Wbm mutation (0 available); any Gab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Placenta defect and small liver size in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm and Gab1^tm2WbmGab1^tm3Wbm mice

embryo

thin placenta labyrinth ( J:125303 )

disorganized placental labyrinth ( J:125303 )

liver/biliary system

decreased liver weight ( J:125303 )

• at E14.5, the liver to body weight ratio is 5.5% compared to 8% in wild-type mice

Allelic Composition	Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1^tm3Wbm mutation (0 available); any Gab1 mutation (78 available)
Met^tm1Cbm mutation (0 available); any Met mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cleft palate in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm, Gab1^tm1Wbm/Gab1^tm1Wbm and Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met⁺ mice, but not in Gab1^tm4Wbm/Gab1^tm4Wbm mice

craniofacial

cleft secondary palate ( J:125303 )

• incidences of cleft palate are enhanced compared to in Gab1^tm3Wbm homozygotes

digestive/alimentary system

cleft secondary palate ( J:125303 )

• incidences of cleft palate are enhanced compared to in Gab1^tm3Wbm homozygotes

growth/size/body

cleft secondary palate ( J:125303 )

• incidences of cleft palate are enhanced compared to in Gab1^tm3Wbm homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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