Phenotypes associated with this allele

• Allele Symbol: Il7r^tm1Abra
• Allele Name: targeted mutation 1, Ninan Abraham
• Allele ID: MGI:3758859
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il7r^tm1Abra/Il7r^tm1Abra	B6.129S4-Il7r^tm1Abra	MGI:3758876

Genotype
MGI:3758876

hm1

• Allelic Composition: Il7r^tm1Abra/Il7r^tm1Abra
• Genetic Background: B6.129S4-Il7r^tm1Abra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell proliferation ( J:125360 )

• unlike in wild-type cells, CD4+ and CD8+ T cells do not proliferate in response to low levels of TCR stimulation but do so in response to high levels of TCR stimulation

decreased thymocyte number ( J:125360 )

• thymic cellularity is reduced 4-fold compared to in wild-type mice

• at all double negative stages, reduction in thymocytes is less severe than in Il7r^tm1Imx homozygotes

• the numbers of gamma delta T cells is decreased relative to in wild-type mice

abnormal T cell differentiation ( J:125360 )

• thymic progenitor cell number is decreased by 20-fold compared to wild-type mice

increased double-positive T cell number ( J:125360 )

• mice have more double positive thymocytes than Il7r^tm1Imx homozygotes

decreased B cell number ( J:125360 )

• while mice have a 3.7+/-1.0 fold decreased in B cells relative to wild-type mice they have more B cells than in Il7r^tm1Imx homozygotes

decreased CD4-positive, alpha-beta T cell number ( J:125360 )

• while mice have a 2.5+/-0.3 fold decreased in CD4+ T cells relative to wild-type mice they have more CD4+ T cells than in Il7r^tm1Imx homozygotes

decreased CD8-positive, alpha-beta T cell number ( J:125360 )

• while mice have a 3.8+/-0.6 fold decreased in CD8+ T cells relative to wild-type mice they have more CD8+ T cells than in Il7r^tm1Imx homzygotes

decreased memory T cell number ( J:125360 )

• 45 days after infection with Listeria monocytogenes expressing an immunodominant foreign, MHC class I (K^b)- restricted peptide, SIYRYYGL, mice have an 8-fold reduction in memory CD8 T cells and very few listeriolysin O-reactive memory CD4 T cells compared to in similarly treated wild-type mice

• re-challenging mice inoculated with Listeria monocytogenes expressing an immunodominant foreign, MHC class I (K^b)- restricted peptide, SIYRYYGL after 100 days increases the number of memory CD8+ T cells but levels are still lower than in similarly treated wild-type mice

• in mice inoculated with an H2-K^b MHC class I-IG fusion protein conjugated to PE loaded with SIY peptide, the number of memory CD8 T cells is reduced by 2.5-fold at day 60 and continues to decrease at day 100 unlike in similarly treated wild type mice

abnormal CD4-positive, alpha-beta T cell physiology ( J:125360 )

• unlike in wild-type cells, CD4 T cells fail to mount a primary response to Listeria monocytogenes expressing an immunodominant foreign, MHC class I (K^b)- restricted peptide, SIYRYYGL

hematopoietic system

abnormal T cell proliferation ( J:125360 )

• unlike in wild-type cells, CD4+ and CD8+ T cells do not proliferate in response to low levels of TCR stimulation but do so in response to high levels of TCR stimulation

decreased thymocyte number ( J:125360 )

• thymic cellularity is reduced 4-fold compared to in wild-type mice

• at all double negative stages, reduction in thymocytes is less severe than in Il7r^tm1Imx homozygotes

• the numbers of gamma delta T cells is decreased relative to in wild-type mice

abnormal T cell differentiation ( J:125360 )

• thymic progenitor cell number is decreased by 20-fold compared to wild-type mice

increased double-positive T cell number ( J:125360 )

• mice have more double positive thymocytes than Il7r^tm1Imx homozygotes

decreased B cell number ( J:125360 )

• while mice have a 3.7+/-1.0 fold decreased in B cells relative to wild-type mice they have more B cells than in Il7r^tm1Imx homozygotes

decreased CD4-positive, alpha-beta T cell number ( J:125360 )

• while mice have a 2.5+/-0.3 fold decreased in CD4+ T cells relative to wild-type mice they have more CD4+ T cells than in Il7r^tm1Imx homozygotes

decreased CD8-positive, alpha-beta T cell number ( J:125360 )

• while mice have a 3.8+/-0.6 fold decreased in CD8+ T cells relative to wild-type mice they have more CD8+ T cells than in Il7r^tm1Imx homzygotes

decreased memory T cell number ( J:125360 )

• 45 days after infection with Listeria monocytogenes expressing an immunodominant foreign, MHC class I (K^b)- restricted peptide, SIYRYYGL, mice have an 8-fold reduction in memory CD8 T cells and very few listeriolysin O-reactive memory CD4 T cells compared to in similarly treated wild-type mice

• re-challenging mice inoculated with Listeria monocytogenes expressing an immunodominant foreign, MHC class I (K^b)- restricted peptide, SIYRYYGL after 100 days increases the number of memory CD8+ T cells but levels are still lower than in similarly treated wild-type mice

• in mice inoculated with an H2-K^b MHC class I-IG fusion protein conjugated to PE loaded with SIY peptide, the number of memory CD8 T cells is reduced by 2.5-fold at day 60 and continues to decrease at day 100 unlike in similarly treated wild type mice

abnormal CD4-positive, alpha-beta T cell physiology ( J:125360 )

• unlike in wild-type cells, CD4 T cells fail to mount a primary response to Listeria monocytogenes expressing an immunodominant foreign, MHC class I (K^b)- restricted peptide, SIYRYYGL

endocrine/exocrine glands

decreased thymocyte number ( J:125360 )

• thymic cellularity is reduced 4-fold compared to in wild-type mice

• at all double negative stages, reduction in thymocytes is less severe than in Il7r^tm1Imx homozygotes

• the numbers of gamma delta T cells is decreased relative to in wild-type mice

cellular

abnormal T cell proliferation ( J:125360 )

• unlike in wild-type cells, CD4+ and CD8+ T cells do not proliferate in response to low levels of TCR stimulation but do so in response to high levels of TCR stimulation