Phenotypes associated with this allele

• Allele Symbol: Taf4^tm1.1Idvd
• Allele Name: targeted mutation 1.1, Irwin davidson
• Allele ID: MGI:3758059
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Taf4^tm1.1Idvd/Taf4^tm1.1Idvd	Not Specified	MGI:3758081

Genotype
MGI:3758081

hm1

• Allelic Composition: Taf4^tm1.1Idvd/Taf4^tm1.1Idvd
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:125257 )

• homozygotes are only detectable until around E9.5

cellular

decreased fibroblast apoptosis ( J:125257 )

• MEFs survive indefinately in serum poor medium whereas MEFs from control mice rapidly undergo apoptosis in the absence of serum

• cell free medium from homozygotes supports survival of heterozygotes in serum poor medium

increased fibroblast proliferation ( J:125257 )

• MEFs in culture grow more rapidly and to a higher density in serum poor medium than do MEFs from control mice