Taf4^tm1.1Idvd
Targeted Allele Detail

Summary

• Symbol: Taf4^tm1.1Idvd
• Name: TATA-box binding protein associated factor 4; targeted mutation 1.1, Irwin davidson
• MGI ID: MGI:3758059
• Gene: Taf4 Location: Chr2:179553945-179618439 bp, - strand Genetic Position: Chr2, 102.42 cM, cytoband H4
• Alliance: Taf4^tm1.1Idvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125257
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A single loxP site was inserted upstream of exon 11 and a floxed hygromycin cassette was inserted in intron 12. ES cells positive for these insertions were also transfected with a cre expressing vector resulting in the excision of exons 11 and 12 as well as the selection cassette. No protein can be identified immunologically in mice homozygous for this allele. (J:125257)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Taf4 Mutation: 42 strains or lines available

References

• Original: J:125257 Mengus G, et al., TAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growth. EMBO J. 2005 Aug 3;24(15):2753-67
• All: 3 reference(s)