Analysis Tools
behavior/neurological
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• treatment with zolpiderm does not produce sedation or overt ataxia
• sensitivity to zolpidem is only restored in Purkinje cells
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• following treatment with 3 mg/kg of zolpidem, mice exhibit reduced ability to stay on a rotating rod
• following treatment with zolpidem, mice need more time to cross a hanging beam than do untreated mice
• however, untreated mice have no motor disabilities, no ataxia or tremor and performed normally on a rotarod test and pre-treatment with flumazenil blocks the effects of zolpiderm
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nervous system
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• mice treated with zolpidem exhibit a raise the amplitude and increase the charge of miniature inhibitory postsynaptic currents (mIPSCs) indicating a restoration of zolpiderm-sensitivity but only in Purkinje cells
• due to mosaic expression of the transgene in female mice with integration into the X chromosome, some mice exhibit a lack of mIPSCsdue to mosaic expression of the transgene in female mice with integration into the X chromosome, some mice exhibit a lack of mIPSCs
• however, in GFP+ cells normal zolpidem-sensitivity is restored
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