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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6/tetO-Gsk3b*S9A)1Rbns
transgene insertion 1, Jeffrey Robbins
MGI:3757954
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Myh6-tTA)55Rbns/0
Tg(Myh6/tetO-Gsk3b*S9A)1Rbns/0 		Not Specified MGI:3757977


Genotype
MGI:3757977
cx1
Allelic
Composition		 Tg(Myh6-tTA)55Rbns/0
Tg(Myh6/tetO-Gsk3b*S9A)1Rbns/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6/tetO-Gsk3b*S9A)1Rbns mutation (0 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased response of heart to induced stress ( J:125131 )
• the normal hypertrophic response to transaortic coarctation (TAC) is blunted in double transgenics in the absence of Dox; when transgenics are kept on Dox and Gsk3b expression is suppressed, they develop hypertrophy comparable to that of controls

homeostasis/metabolism
decreased response of heart to induced stress ( J:125131 )
• the normal hypertrophic response to transaortic coarctation (TAC) is blunted in double transgenics in the absence of Dox; when transgenics are kept on Dox and Gsk3b expression is suppressed, they develop hypertrophy comparable to that of controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory