Tg(Myh6/tetO-Gsk3b*S9A)1Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-Gsk3b*S9A)1Rbns
• Name: transgene insertion 1, Jeffrey Robbins
• MGI ID: MGI:3757954
• Synonyms: MHCmin^TetO-GSK-CA
• Transgene: Tg(Myh6/tetO-Gsk3b*S9A)1Rbns Location: unknown
• Alliance: Tg(Myh6/tetO-Gsk3b*S9A)1Rbns page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: This transgene contains constitutively active Gsk3b (an S9A mutation was introduced to make it constitutively active) under transcriptional control of a minimally active mouse alpha myosin heavy chain (Myh6) promoter fused to seven copies of the tetracycline-responsive promoter element (tetO). To make the Myh6 promoter minimally active, three GATA sites and two thyroid-like response elements are ablated. When bred with transgenic mice expressing a tetracycline transactivator or reverse transactivator protein, cardiac-specific expression of the constitutively active Gsk3b can be controlled by withdrawal or administration of a tetracycline analog. (J:125131)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:125131 Sanbe A, et al., Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res. 2003 Apr 4;92(6):609-16
• All: 1 reference(s)