Phenotypes associated with this allele

• Allele Symbol: Dbx1^tm1(DTA)Apie
• Allele Name: targeted mutation 1, Alessandra Pierani
• Allele ID: MGI:3757953
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dbx1^tm1(DTA)Apie/Dbx1^+ Pax7^tm1(cre)Mrc/Pax7^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4837354
cn2	Dbx1^tm1(DTA)Apie/Dbx1^+ Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3770261

Genotype
MGI:4837354

cn1

• Allelic Composition: Dbx1^tm1(DTA)Apie/Dbx1⁺; Pax7^tm1(cre)Mrc/Pax7⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:165285 )

N • at E15.5, rhythmic activity in the pre-Botzinger complex is preserved

Genotype
MGI:3770261

cn2

• Allelic Composition: Dbx1^tm1(DTA)Apie/Dbx1⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

nervous system

abnormal cerebral cortex morphology ( J:101434 )

• differences in cortical cytoarchitecture were observed in both rostral and caudal level

• the mutant cortex did not show a typical Reeler phenotype

abnormal olfactory cortex morphology ( J:101434 )

• strong decrease to a complete loss of Reelin expressing cells in the rostrocaudal axis of the telencephalic vesicles and of the olfactory bulb at E11.5 and E12.5

• no significant differences in Reelin expression in cortex of the wild-type and mutant at E14.5