Analysis Tools
mortality/aging
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• all mice are born alive but die within a few hours after birth
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nervous system
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• unlike mice homozygous for Sox10tm1Weg, cranial and sympathetic ganglia morphology are similar to wild-type
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• stomach wall contains a fully developed enteric nervous system (ENS) at E18.5 in contrast to the complete lack of ENS in Sox10tm1Weg
• few enteric neural crest, neurons or glia cells are detected in small or large intestine
• colonization of the intestines by enteric nervous system cells is variable but never goes beyond the duodenum
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• the number of myelinating oligodendrocytes is reduced to about 65% of wild-type levels
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• expression analysis indicates that Schwann cells fail to mature to the myelinating stage by E18.5
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• levels of apoptosis in glia and neuronal cells are increased at E14.5 embryos while expression on the mutant protein is decrease
• severe reduction in size at E18.5
• however, unlike mice homozygous for Sox10tm1Weg ganglia morphology is similar to wild-type at E10.5 and E11.5
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embryo
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• the number of migrating melanoblasts near the eye of E12.5 embryos are reduced
• number of melanoblasts in E12.5 embryos in the hindlimb region is 20% of that found in wild-type
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cellular
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• the number of migrating melanoblasts near the eye of E12.5 embryos are reduced
• number of melanoblasts in E12.5 embryos in the hindlimb region is 20% of that found in wild-type
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