Analysis Tools
mortality/aging
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• embryos die between E10.5 and E11.5 due to widespread failure of cell viability
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embryo
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• increased apoptosis of cells within the head mesenchyme particularly in the area of the trigeminal neural crest at E8.5-E10.5
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• growth restriction occurs between E8.5-E10.5 of development
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• prior to death at E10.5, embryos are smaller than wild-type controls
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• at E10.5 ruffles are seen in the neuroectoderm of the neural tube of some embryos
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• embryos exhibit a failure of neural tube closure from the hindbrain rostrally
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growth/size/body
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• increased apoptosis of cells within the head mesenchyme particularly in the area of the trigeminal neural crest at E8.5-E10.5
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• growth restriction occurs between E8.5-E10.5 of development
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• prior to death at E10.5, embryos are smaller than wild-type controls
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nervous system
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• increased apoptosis in neural tube at E8.5-E10.5
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• at E10.5 ruffles are seen in the neuroectoderm of the neural tube of some embryos
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• embryos exhibit a failure of neural tube closure from the hindbrain rostrally
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exencephaly
(
J:124662
)
cellular
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• a sharp increase is seen in the number of cells with 3 or more lipid droplets in the cytoplasm particularly in the mesenchyme and cardiovascular tissues at E8.5 - E10.5
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• embryonic cells display a 4-fold increase in Golgi body number and the Golgi bodies have dilated membranes and an increase in smooth and dense vesicles
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• the rough endoplasmic reticulum has fewer ribosomes compared to wild-type embryonic cells
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• increased apoptosis of cells within the head mesenchyme particularly in the area of the trigeminal neural crest at E8.5-E10.5
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• increased apoptosis in neural tube at E8.5-E10.5
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