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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clca1tm1Dgen
targeted mutation 1, Deltagen
MGI:3722629
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Clca1tm1Dgen/Clca1tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3723241


Genotype
MGI:3723241
hm1
Allelic
Composition		 Clca1tm1Dgen/Clca1tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clca1tm1Dgen mutation (0 available); any Clca1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:112942 )
• in two asthma models, mice fail to attenuate the inflammatory response after allergen (ovalbumin) challenge
• following exposure to ovalbumin, mice develop an exacerbated mucin secretory response compared to wild-type mice
• following exposure to ovalbumin or IL-13, Muc5ac levels are increased compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory