Clca1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Clca1^tm1Dgen
• Name: chloride channel accessory 1; targeted mutation 1, Deltagen
• MGI ID: MGI:3722629
• Synonyms: Gob-5 KO
• Gene: Clca1 Location: Chr3:144710298-144738537 bp, - strand Genetic Position: Chr3, 69.26 cM
• Alliance: Clca1^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112942
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ neo reporter gene replaced a 244 bp segment of the coding region spanning exons 7 and 8, which encode the putative C-terminal region of the transmembrane domain and the second intracellular region. Homozygous mice did not express detectable levels of protein in colon or lung from this allele. (J:112942)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clca1 Mutation: 57 strains or lines available

References

• Original: J:112942 Robichaud A, et al., Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma. Am J Respir Cell Mol Biol. 2005 Sep;33(3):303-14
• All: 1 reference(s)