Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Jmg mutation
(1 available);
any
Cd28 mutation
(53 available)
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immune system
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• mice have reduced airway hyperresponsiveness after sensitization and challenge with OVA
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• T cells secrete less IL-2 when activated compared to controls
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• mice fail to develop EAE after immunization with MOG but do have inflammatory infiltrates into the spinal cord
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Allelic Composition |
Cd28tm1Jmg/Cd28tm1Jmg
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Genetic Background |
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Jmg mutation
(1 available);
any
Cd28 mutation
(53 available)
|
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immune system
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• a mixed lymphocyte culture with alloantigen failed to proliferate
• proliferation of T cell in response to anti-CD3 alone and to the combination of anti-CD3 + anti-CD28
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• mutant mice sensitized and challenged with OVA fails to develop germinal centers in the spleen
• mutant animals show a normal inflammatory response to OVA stimulation
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• mutant mice sensitized and challenged with OVA shows a marked decrease in OVA-specific antibody
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• a substantial reduction in the amount of several cytokines in the culture supernatants of stimulated T cells
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• reduced IL-2 present in the culture supernatants of stimulated T cells
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hematopoietic system
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• a mixed lymphocyte culture with alloantigen failed to proliferate
• proliferation of T cell in response to anti-CD3 alone and to the combination of anti-CD3 + anti-CD28
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• mutant mice sensitized and challenged with OVA fails to develop germinal centers in the spleen
• mutant animals show a normal inflammatory response to OVA stimulation
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• mutant mice sensitized and challenged with OVA shows a marked decrease in OVA-specific antibody
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Allelic Composition |
Cd28tm1Jmg/Cd28tm1Mak
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Genetic Background |
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 |
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immune system
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• a marked defect in proliferative response to anti-CD3 alone and to the combination of anti-CD3 + anti-CD28
(J:124570)
• T cells have impaired proliferation in response to T cell co-stimulation (anti-CD3 + anti-CD28) that can be partially rescued by high level of anti-CD28 antibody
(J:149888)
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• a mixed lymphocyte culture with alloantigen failed to proliferate
|
|
• mutant mice sensitized and challenged with OVA fails to develop germinal centers in the spleen
• mutant animals show a normal inflammatory response to OVA stimulation
|
|
• mutant mice sensitized and challenged with OVA shows a marked decrease in OVA-specific antibody
|
|
• a substantial reduction in the amount of several cytokines in the culture supernatants of stimulated T cells
|
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• no detectable IL-2 present in the culture supernatants of stimulated T cells
|
hematopoietic system
|
• a marked defect in proliferative response to anti-CD3 alone and to the combination of anti-CD3 + anti-CD28
(J:124570)
• T cells have impaired proliferation in response to T cell co-stimulation (anti-CD3 + anti-CD28) that can be partially rescued by high level of anti-CD28 antibody
(J:149888)
|
|
• a mixed lymphocyte culture with alloantigen failed to proliferate
|
|
• mutant mice sensitized and challenged with OVA fails to develop germinal centers in the spleen
• mutant animals show a normal inflammatory response to OVA stimulation
|
|
• mutant mice sensitized and challenged with OVA shows a marked decrease in OVA-specific antibody
|
cellular
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• a marked defect in proliferative response to anti-CD3 alone and to the combination of anti-CD3 + anti-CD28
(J:124570)
• T cells have impaired proliferation in response to T cell co-stimulation (anti-CD3 + anti-CD28) that can be partially rescued by high level of anti-CD28 antibody
(J:149888)
|