Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Tg(KRT5-cre/PGR)1Der mutation
(0 available)
Trp53tm1Brn mutation
(18 available);
any
Trp53 mutation
(232 available)
Trp53tm3Glo mutation
(0 available);
any
Trp53 mutation
(232 available)
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neoplasm
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• following treatment with RU486 and TPA, mice develop more tumors than in Krastm4Tyj Trp53tm1Brn/ Trp53tm1Brn Tg(KRT5-cre/PGR)1Der mice
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• following treatment with RU486 and TPA, conversion to malignant carcinoma is accelerated relative to in Krastm4Tyj Trp53tm1Brn/ Trp53tm1Brn Tg(KRT5-cre/PGR)1Der mice
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• after RU486 and TPA treatment, 60% of tumors that develop are spindle cell carcinomas
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Tg(KRT5-cre/PGR)1Der mutation
(0 available)
Trp53tm3Glo mutation
(0 available);
any
Trp53 mutation
(232 available)
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neoplasm
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• after RU486 and TPA treatment, mice develop three-fold more tumors than Krastm4Tyj Trp53tm1Brn heterozygotes and Krastm4Tyj Tg(KRT5-cre/PGR)1Der heterozygotes
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• after RU486 and TPA treatment, 60% of mice develop metastasis in the lungs and/or lymph nodes compared to no wild-type mice
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• after RU486 and TPA treatment, 42% of tumors exhibit aneuplody compared to 23% of Krastm4Tyj Trp53tm1Brn heterozygotes and 20% of Krastm4Tyj Tg(KRT5-cre/PGR)1Der heterozygotes
• after RU486 and TPA treatment, tumors exhibit centrosome amplification in 3% to 5% of tumors cells
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• after RU486 and TPA treatment, carcinoma development is accelerated compared to in Krastm4Tyj Trp53tm1Brn heterozygotes and Krastm4Tyj Tg(KRT5-cre/PGR)1Der heterozygotes
• after RU486 and TPA treatment, 90% of mice develop skin carcinomas compared to 30% of Krastm4Tyj Trp53tm1Brn heterozygotes and 5% of Krastm4Tyj Tg(KRT5-cre/PGR)1Der heterozygotes
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cellular
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• after RU486 and TPA treatment, tumors exhibit centrosome amplification in 3% to 5% of tumors cells
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homeostasis/metabolism