All Phenotypes Ifna6<tm1Aki> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ifna6^tm1Aki/Ifna6⁺	Not Specified	MGI:3808908
cx2	Ifna6^tm1Aki/Ifna6⁺ Myd88^tm1Aki/Myd88^tm1Aki	involves: 129P2/OlaHsd	MGI:3808910
cx3	Mavs^tm1Aki/Mavs^tm1Aki Ifna6^tm1Aki/Ifna6⁺	involves: 129P2/OlaHsd	MGI:3808911

Allelic Composition	Ifna6^tm1Aki/Ifna6⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifna6^tm1Aki mutation (0 available); any Ifna6 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:124340 )

• mice are viable and fertile

• production of IFNalpha in response to viral infection is unimpaired

Allelic Composition	Ifna6^tm1Aki/Ifna6⁺ Myd88^tm1Aki/Myd88^tm1Aki
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifna6^tm1Aki mutation (0 available); any Ifna6 mutation (16 available)
Myd88^tm1Aki mutation (9 available); any Myd88 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal plasmacytoid dendritic cell morphology ( J:124340 )

• there is more than a 10-fold drop in the percentage of plasmacytoid dendritic cells that are GFP⁺ in response to Newcastle disease virus (NDV) infection when compared to controls

decreased interferon-alpha secretion ( J:124340 )

• levels of IFN-alpha are decreased 2 to 12 hours after infection with NDV compared to controls

hematopoietic system

abnormal plasmacytoid dendritic cell morphology ( J:124340 )

• there is more than a 10-fold drop in the percentage of plasmacytoid dendritic cells that are GFP⁺ in response to Newcastle disease virus (NDV) infection when compared to controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal myeloid dendritic cell morphology ( J:124340 )

• GFP⁺ conventional dendritic cell numbers are significantly lower compared to controls after NDV infection

abnormal macrophage morphology ( J:124340 )

• GFP⁺ macrophage numbers are significantly lower compared to controls after NDV infection

abnormal alveolar macrophage morphology ( J:124340 )

• GFP⁺ alveolar macrophage numbers are severely reduced after Newcastle disease virus (NDV) infection compared to controls

decreased interferon-alpha secretion ( J:124340 )

• levels of IFN-alpha are severely decreased 2 to 6 hours after infection with NDV compared to controls

• levels of IFN-alpha remain below what is found in controls for 24 hours after infection

hematopoietic system

abnormal myeloid dendritic cell morphology ( J:124340 )

• GFP⁺ conventional dendritic cell numbers are significantly lower compared to controls after NDV infection

abnormal macrophage morphology ( J:124340 )

• GFP⁺ macrophage numbers are significantly lower compared to controls after NDV infection

abnormal alveolar macrophage morphology ( J:124340 )

• GFP⁺ alveolar macrophage numbers are severely reduced after Newcastle disease virus (NDV) infection compared to controls

respiratory system

abnormal alveolar macrophage morphology ( J:124340 )

• GFP⁺ alveolar macrophage numbers are severely reduced after Newcastle disease virus (NDV) infection compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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