Phenotypes associated with this allele

• Allele Symbol: Bmal1^tm1Weit
• Allele Name: targeted mutation 1, Charles Weitz
• Allele ID: MGI:3720808
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bmal1^tm1Bra/Bmal1^tm1Weit Syt10^tm1.1(icre)Geno/Syt10^+	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6	MGI:5297480
cn2	Bmal1^tm1Bra/Bmal1^tm1Weit Syt10^tm1.1(icre)Geno/Syt10^tm1.1(icre)Geno	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6	MGI:5297485
cn3	Bmal1^tm1Weit/Bmal1^tm1Weit Syt10^tm1.1(icre)Geno/Syt10^+	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6	MGI:5297479
cn4	Bmal1^tm1Weit/Bmal1^tm1Weit Tg(Chx10-EGFP/cre,-ALPP)2Clc/0	involves: 129S4/SvJae * C57BL/6	MGI:3720976

Genotype
MGI:5297480

cn1

• Allelic Composition: Bmal1^tm1Bra/Bmal1^tm1Weit; Syt10^{tm1.1(icre)Geno}/Syt10⁺
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal circadian behavior ( J:175596 )

• animals display impaired activity rhythms but are not totally arrhythmic

shortened circadian behavior period ( J:175596 )

• animals have a shorter period in constant light conditions (DD); mutants have higher onset errors than wild-type controls

Genotype
MGI:5297485

cn2

• Allelic Composition: Bmal1^tm1Bra/Bmal1^tm1Weit; Syt10^{tm1.1(icre)Geno}/Syt10^{tm1.1(icre)Geno}
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

behavior/neurological

abnormal circadian behavior ( J:175596 )

• almost all animals display essentially no circadian rhythmicity (no clear circadian peak)

• under light-dark conditions (LD; 12:12 light/dark cycle), mutants are more active than wild-type in the light phase

• in animals, decreasing circadian amplitudes correlate with increasing ultradian amplitudes

Genotype
MGI:5297479

cn3

• Allelic Composition: Bmal1^tm1Weit/Bmal1^tm1Weit; Syt10^{tm1.1(icre)Geno}/Syt10⁺
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

behavior/neurological

shortened circadian behavior period ( J:175596 )

• mice show a shortened period under constant dark conditions (DD) compared to controls; animals are still rhythmic under constant light and dark conditions, but rhythmicity under DD is less stable compared to controls (mutants show increased onset variability relative to controls)

Genotype
MGI:3720976

cn4

• Allelic Composition: Bmal1^tm1Weit/Bmal1^tm1Weit; Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6

vision/eye

abnormal eye electrophysiology ( J:124157 )

• under dark-adapted conditions, amplitude of b-wave is reduced by 27%, causing significant reduction in b-wave to a-wave amplitude ratio

• under light-adapted conditions, b-wave amplitude is reduced by 44%

• no detectable circadian rhythm of b-wave amplitude is observed, with b-wave responses apparently fixed at low amplitude at times of both high and low b-wave amplitude (circadian times CT 6 and CT 18)

• no circadian rhythm of b-wave implicit time (time between light stimulus and peak of b-wave) is detectable, whereas this is robust in controls