Syt10tm1.1(icre)Geno
Targeted Allele Detail
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Symbol: |
Syt10tm1.1(icre)Geno |
Name: |
synaptotagmin X; targeted mutation 1.1, Genoway |
MGI ID: |
MGI:5286607 |
Synonyms: |
Syt10Cre |
Gene: |
Syt10 Location: Chr15:89666596-89726063 bp, - strand Genetic Position: Chr15, 44.96 cM, cytoband F1
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Alliance: |
Syt10tm1.1(icre)Geno page
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Germline Transmission: |
Earliest citation of germline transmission:
J:175596
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Recombinase) |
Mutations: |
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Insertion, Intragenic deletion
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Syt10tm1.1(icre)Geno expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A targeting construct containing cre recombinase, an IRES, and cDNA encoding EGFP replaced the Syt10 exon 1 sequence following the initiating ATG codon in ES cells. An Frt-flanked neomycin selection cassette after the EGFP sequence was also included. This was subsequently deleted from F1 animals by crossing to Gt(ROSA)26Sortm1(FLP1)Dym mice on a C57BL/6 background. No transcripts of Syt10 are detected in the suprachiasmatic nuclei or other sites of endogenous expression in the brain. Breeding experiments show that cre is active in the male germline.
(J:175596)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Syt10
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Syt10 Mutation: |
35 strains or lines available
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Original: |
J:175596 Husse J, et al., Synaptotagmin10-Cre, a Driver to Disrupt Clock Genes in the SCN. J Biol Rhythms. 2011 Oct;26(5):379-89 |
All: |
4 reference(s) |
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