Phenotypes associated with this allele

• Allele Symbol: Tg(APOE-DGAT2)1Far
• Allele Name: transgene insertion 1, Bob Farese
• Allele ID: MGI:3720367
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(APOE-DGAT2)1Far/0	involves: C57BL/6NHsd	MGI:3720391

Genotype
MGI:3720391

tg1

• Allelic Composition: Tg(APOE-DGAT2)1Far/0
• Genetic Background: involves: C57BL/6NHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

enlarged liver ( J:124005 )

• resulting from steatosis; liver weight to body weight ratio (0.050) is higher than in wild-type mice

liver inflammation ( J:124005 )

• liver phosphorylation levels of PERK, a kinase involved in the ER stress response, is increased relative to Tg(APOE-DGAT2)24Far mice

hepatic steatosis ( J:124005 )

• steatosis exhibited by increase in size and paleness of livers; proportionally greater than in low-expressing Tg(APOE-DGAT2)24Far

pale liver ( J:124005 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:124005 )

N • food intake and body composition are not altered compared to wild-type animals

N • plasma levels of adipokines and inflammatory cytokines are similar to wild-type mice

N • blood glucose and insulin levels are similar to wild-type mice; transgenic mice do not display differences in glucose or insulin tolerance so mice are not insulin resistant

increased circulating alanine transaminase level ( J:124005 )

• plasma transaminase levels are 2- to 3-fold higher than in wild-type

increased circulating aspartate transaminase level ( J:124005 )

• plasma transaminase levels are 2- to 3-fold higher than in wild-type

abnormal lipid level ( J:124005 )

• tissue content of diacylglycerol and ceramides are increased in liver, proportionally more than in Tg(APOE-DGAT2)24Far mice; however, levels in skeletal muscle are not altered

decreased circulating triglyceride level ( J:124005 )

abnormal fatty acids level ( J:124005 )

• content of unsaturated long-chain fatty acyl-CoAs are increased in the liver, but levels of saturated long-chain fatty acyl-CoAs are not

decreased circulating free fatty acids level ( J:124005 )

• plasma levels are slightly decreased relative to wild-type

increased triglyceride level ( J:124005 )

• triglyceride content is increased ~17-fold over wild-type

immune system

liver inflammation ( J:124005 )

• liver phosphorylation levels of PERK, a kinase involved in the ER stress response, is increased relative to Tg(APOE-DGAT2)24Far mice

growth/size/body

enlarged liver ( J:124005 )

• resulting from steatosis; liver weight to body weight ratio (0.050) is higher than in wild-type mice